Astrocyte ERK phosphorylation precedes K+-induced swelling but follows hypotonicity-induced swelling
2010; Wiley; Volume: 31; Issue: 3 Linguagem: Inglês
10.1111/j.1440-1789.2010.01172.x
ISSN1440-1789
AutoresLiping Cai, Ting Du, Dan Song, Baoman Li, Leif Hertz, Liang Peng,
Tópico(s)Neuroscience and Neuropharmacology Research
ResumoNeuropathologyVolume 31, Issue 3 p. 250-264 Astrocyte ERK phosphorylation precedes K+-induced swelling but follows hypotonicity-induced swelling Liping Cai, Liping Cai Department of Clinical Pharmacology, China Medical University Laboratory of Molecular Biology, Liaoning University of Traditional Chinese Medicine, Shenyang, ChinaSearch for more papers by this authorTing Du, Ting Du Department of Clinical Pharmacology, China Medical UniversitySearch for more papers by this authorDan Song, Dan Song Department of Clinical Pharmacology, China Medical UniversitySearch for more papers by this authorBaoman Li, Baoman Li Department of Clinical Pharmacology, China Medical UniversitySearch for more papers by this authorLeif Hertz, Leif Hertz Department of Clinical Pharmacology, China Medical UniversitySearch for more papers by this authorLiang Peng, Corresponding Author Liang Peng Department of Clinical Pharmacology, China Medical UniversityLiang Peng, MD PhD, College of Basic Medical Sciences, China Medical University, No. 92 Beier Road, Heping District, Shenyang 110001, China. Email: [email protected]Search for more papers by this author Liping Cai, Liping Cai Department of Clinical Pharmacology, China Medical University Laboratory of Molecular Biology, Liaoning University of Traditional Chinese Medicine, Shenyang, ChinaSearch for more papers by this authorTing Du, Ting Du Department of Clinical Pharmacology, China Medical UniversitySearch for more papers by this authorDan Song, Dan Song Department of Clinical Pharmacology, China Medical UniversitySearch for more papers by this authorBaoman Li, Baoman Li Department of Clinical Pharmacology, China Medical UniversitySearch for more papers by this authorLeif Hertz, Leif Hertz Department of Clinical Pharmacology, China Medical UniversitySearch for more papers by this authorLiang Peng, Corresponding Author Liang Peng Department of Clinical Pharmacology, China Medical UniversityLiang Peng, MD PhD, College of Basic Medical Sciences, China Medical University, No. 92 Beier Road, Heping District, Shenyang 110001, China. Email: [email protected]Search for more papers by this author First published: 01 December 2010 https://doi.org/10.1111/j.1440-1789.2010.01172.xCitations: 25 L. Cai and T. Du contributed equally to this article. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Hypotonicity following water intoxication and/or salt loss leads to mainly astrocytic brain swelling. Astrocytic swelling also occurs following brain trauma or ischemia, together with an increase in extracellular K+ ([K+]o), stimulating a bumetanide/furosemide/ethacrynic acid-inhibitable cotransporter, NKCC1, that accumulates Na+ and K+ together with 2 Cl- and osmotically obliged water. Either type of swelling may become fatal and is associated with phosphorylation of extracellular regulated kinases 1 and 2 (ERK1/2). Only the swelling associated with elevated [K+]o, leads to an increase in astrocytic proliferation and in expression of the astrocytic marker, glial fibrillary acidic protein. These differences prompted us to investigate key aspects of the molecular pathways between hypotonicity-induced and high-K+-mediated swelling in primary cultures of mouse astrocytes. 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