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Disease course and viral shedding in experimental Norwalk virus and Snow Mountain virus infection

2014; Wiley; Volume: 86; Issue: 12 Linguagem: Inglês

10.1002/jmv.23905

1096-9071

Amy Kirby, Jing Shi, Julia Montes, Meredith Lichtenstein, Christine L. Moe,

Respiratory viral infections research

Journal of Medical VirologyVolume 86, Issue 12 p. 2055-2064 Research Article Disease course and viral shedding in experimental Norwalk virus and Snow Mountain virus infection A.E. Kirby, A.E. Kirby orcid.org/0000-0002-6928-668X Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GeorgiaSearch for more papers by this authorJ. Shi, J. Shi Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GeorgiaSearch for more papers by this authorJ. Montes, J. Montes Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GeorgiaSearch for more papers by this authorM. Lichtenstein, M. Lichtenstein Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GeorgiaSearch for more papers by this authorC.L. Moe, Corresponding Author C.L. Moe Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia Correspondence to: Christine L. Moe, MS002-7BB (SPH:GH), 1518 Clifton Rd. NE, Atlanta, GA 30322. E-mail: clmoe@emory.eduSearch for more papers by this author A.E. Kirby, A.E. Kirby orcid.org/0000-0002-6928-668X Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GeorgiaSearch for more papers by this authorJ. Shi, J. Shi Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GeorgiaSearch for more papers by this authorJ. Montes, J. Montes Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GeorgiaSearch for more papers by this authorM. Lichtenstein, M. Lichtenstein Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GeorgiaSearch for more papers by this authorC.L. Moe, Corresponding Author C.L. Moe Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia Correspondence to: Christine L. Moe, MS002-7BB (SPH:GH), 1518 Clifton Rd. NE, Atlanta, GA 30322. E-mail: clmoe@emory.eduSearch for more papers by this author First published: 14 February 2014 https://doi.org/10.1002/jmv.23905Citations: 57 The authors have no conflicts of interest to disclose. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Norovirus is the most common cause of acute infectious gastroenteritis, causing approximately 21 million cases annually in the USA. The virus is highly contagious and resistant to decontamination, making outbreaks difficult to control. To facilitate the development of better control methods, this study characterized the viral shedding patterns in stools from subjects experimentally infected with genogroup I or II norovirus. Viral stool titers were determined by quantitative real-time RT-PCR for all stools produced in the first 7 days post-challenge and representative stools through day 35 post-challenge. The shedding titers and disease course were analyzed with respect to virus type, illness, and subject demographics. Infection with GII.2 Snow Mountain (SMV) resulted in more symptoms and a higher frequency of painful symptoms compared to GI.1 Norwalk (NV) infection. However, NV infection produced stool viral titers approximately 2 logs higher than those seen in SMV infections. Both NV and SMV were shed in stools for up to 3 weeks after the resolution of symptoms, but long shedding durations were more common in NV infections. For each challenge virus, shedding titers and patterns were not correlated with subject demographics or clinical course. This is the first study to report shedding dynamics in experimental GII norovirus infection. J. Med. Virol. 86:2055–2064, 2014. © 2014 Wiley Periodicals, Inc. Citing Literature Volume86, Issue12December 2014Pages 2055-2064 RelatedInformation