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Divergent Cognitive Status with the Same Braak Stage of Neurofibrillary Pathology: Does the Pattern of Amyloid-β Deposits Make the Difference?

2014; IOS Press; Volume: 43; Issue: 2 Linguagem: Inglês

10.3233/jad-140540

1875-8908

Emanuela Maderna, Cristina Cattaneo, Francesca Cacciatore, Marcella Catania, Giuseppe Di Fede, Fabrizio Tagliavini, Giorgio Giaccone,

Neurological Disease Mechanisms and Treatments

The neuropathological hallmark of Alzheimer's disease (AD) is the co-occurrence of extracellular amyloid-β (Aβ) deposition and intraneuronal neurofibrillary changes composed of abnormal tau. Over the last decades, the concept emerged that neurofibril