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Multiple roles of tumor necrosis factor-alpha in fracture healing

2015; Elsevier BV; Volume: 78; Linguagem: Inglês

10.1016/j.bone.2015.05.001

8756-3282

Jonathan Karnes, Scott D. Daffner, Colleen M. Watkins,

Bone Metabolism and Diseases

This review presents a summary of basic science evidence examining the influence of tumor necrosis factor-alpha (TNF-α) on secondary fracture healing. Multiple studies suggest that TNF-α, in combination with the host reservoir of peri-fracture mesenchymal stem cells, is a main determinant in the success of bone healing. Disease states associated with poor bone healing commonly have inappropriate TNF-α responses, which likely contributes to the higher incidence of delayed and nonunions in these patient populations. Appreciation of TNF-α in fracture healing may lead to new therapies to augment recovery and reduce the incidence of complications.