Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation
2015; Cell Press; Volume: 11; Issue: 8 Linguagem: Inglês
10.1016/j.celrep.2015.04.043
ISSN2639-1856
AutoresSara Calafate, Arjan Buist, Katarzyna Miśkiewicz, V. A. Vijayan, Guy Daneels, Bart De Strooper, Joris de Wit, Patrik Verstreken, Diederik Moechars,
Tópico(s)Neuroscience and Neuropharmacology Research
ResumoIn BriefTau dysfunction causes neurodegeneration, and tau pathology spreading appears to occur along synaptically connected neurons.However, it is not known whether the actual presence of synapses enhances spreading.Using artificial neuronal circuits in vitro, Calafate et al. show that synaptic contacts promote spreading and that synaptic and non-synaptic mechanisms act in parallel.
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