Suppression of TNF-α-Induced Apoptosis by NF-κB
1996; American Association for the Advancement of Science; Volume: 274; Issue: 5288 Linguagem: Inglês
10.1126/science.274.5288.787
ISSN1095-9203
AutoresDaniel J. Van Antwerp, Séamus J. Martin, Tal Kafri, Douglas R. Green, Inder M. Verma,
Tópico(s)interferon and immune responses
ResumoTumor necrosis factor α (TNF-α) signaling gives rise to a number of events, including activation of transcription factor NF-κB and programmed cell death (apoptosis). Previous studies of TNF-α signaling have suggested that these two events occur independently. The sensitivity and kinetics of TNF-α-induced apoptosis are shown to be enhanced in a number of cell types expressing a dominant-negative IκBα (IκBαM). These findings suggest that a negative feedback mechanism results from TNF-α signaling in which NF-κB activation suppresses the signals for cell death.
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