Portal de Periódicos da CAPES

Antibody response to BK polyomavirus as a prognostic biomarker and potential therapeutic target in prostate cancer

2015; Impact Journals LLC; Volume: 6; Issue: 8 Linguagem: Inglês

10.18632/oncotarget.3363

1949-2553

Etienne Xavier Keller, Piotr Kardas, Claudio Acevedo, Giovanni Sais, Cédric Poyet, Irina Banzola, Ashkan Mortezavi, Burkhardt Seifert, Tullio Sulser, Hans H. Hirsch, Maurizio Provenzano,

Parvovirus B19 Infection Studies

// Xavier Etienne Keller 1 , Piotr Kardas 2 , Claudio Acevedo 1 , Giovanni Sais 1 , Cédric Poyet 1 , Irina Banzola 1 , Ashkan Mortezavi 1 , Burkhardt Seifert 3 , Tullio Sulser 1 , Hans H. Hirsch 2,4,* and Maurizio Provenzano 1,* 1 Oncology Research Unit, Division of Urology and Division of Surgical Research, University Hospital Zurich, CH-8091 Zurich, Switzerland 2 Transplantation and Clinical Virology, Department Biomedicine (Haus Petersplatz), University of Basel, CH-4003 Basel, Switzerland 3 Epidemiology, Biostatistics and Prevention Institute, University of Zurich, CH-8001 Zurich, Switzerland 4 Infectious Diseases & Hospital Epidemiology, University Hospital Basel, CH-4031 Basel, Switzerland * These authors contributed equally to this work Correspondence: Maurizio Provenzano, email: // Keywords : BK polyomavirus, prostate cancer, prognosis, antibody response, biochemical recurrence Received : December 03, 2014 Accepted : January 15, 2015 Published : January 31, 2015 Abstract Infectious agents, including the BK polyomavirus (BKPyV), have been proposed as important inflammatory pathogens in prostate cancer. Here, we evaluated whether the preoperative antibody response to BKPyV large T antigen (LTag) and viral capsid protein 1 (VP1) was associated with the risk of biochemical recurrence in 226 patients undergoing radical prostatectomy for primary prostate cancer. Essentially, the multivariate Cox regression analysis revealed that preoperative seropositivity to BKPyV LTag significantly reduced the risk of biochemical recurrence, independently of established predictors of biochemical recurrence such as tumor stage, Gleason score and surgical margin status. The predictive accuracy of the regression model was denotatively increased by the inclusion of the BKPyV LTag serostatus. In contrast, the VP1 serostatus was of no prognostic value. Finally, the BKPyV LTag serostatus was associated with a peculiar cytokine gene expression profile upon assessment of the cellular immune response elicited by LTag. Taken together, our findings suggest that the BKPyV LTag serology may serve as a prognostic factor in prostate cancer. If validated in additional studies, this biomarker may allow for better treatment decisions after radical prostatectomy. Finally, the favorable outcome of LTag seropositive patients may provide a potential opportunity for novel therapeutic approaches targeting a viral antigen.