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Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis

2010; American Association for the Advancement of Science; Volume: 330; Issue: 6006 Linguagem: Inglês

10.1126/science.1194516

1095-9203

Yvonne S. Eisele, Ulrike Obermüller, Götz Heilbronner, Frank Baumann, Stephan A. Kaeser, Hartwig Wolburg, Lary C. Walker, Matthias Staufenbiel, Mathias Heikenwälder, Mathias Jucker,

Endoplasmic Reticulum Stress and Disease

Infectious Amyloid? Patients with Alzheimer's disease have characteristic lesions in the brains associated with masses of polymerized protein called β-amyloid. Recently, evidence from mouse models of Alzheimer's disease shows that brain extracts containing β-amyloid can “infect” otherwise healthy animals when injected directly into their brains. Eisele et al. (p. 980 , published online 21 October; see the Perspective by Kim and Holtzman ) extend these findings to show that when mice are injected in other parts of their bodies with similar brain extracts after several months, they also develop amyloidosis within their brains.