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RARβ involvement in enhancement of lung tumor cell immunogenicity revealed by array analysis

2000; Wiley; Volume: 14; Issue: 9 Linguagem: Inglês

10.1096/fasebj.14.9.1224

1530-6860

André Toulouse, Martine Loubeau, Johane Morin, Jane J. Pappas, Jiangping Wu, W. E. C. Bradley,

interferon and immune responses

The FASEB JournalVolume 14, Issue 9 p. 1224-1232 ReviewFree to Read RARβ involvement in enhancement of lung tumor cell immunogenicity revealed by array analysis Andre Toulouse, Andre Toulouse Institut du Cancer de Montreal, Montreal, Qc, H2L 4M1 Canada Centre de Recherche du CHUM 1560 Sherbrooke E., Montreal, Qc, H2L 4M1 CanadaSearch for more papers by this authorMartine Loubeau, Martine Loubeau Centre de Recherche du CHUM 1560 Sherbrooke E., Montreal, Qc, H2L 4M1 CanadaSearch for more papers by this authorJohane Morin, Johane Morin Institut du Cancer de Montreal, Montreal, Qc, H2L 4M1 Canada Centre de Recherche du CHUM 1560 Sherbrooke E., Montreal, Qc, H2L 4M1 CanadaSearch for more papers by this authorJane J. Pappas, Jane J. Pappas Institut du Cancer de Montreal, Montreal, Qc, H2L 4M1 Canada Centre de Recherche du CHUM 1560 Sherbrooke E., Montreal, Qc, H2L 4M1 CanadaSearch for more papers by this authorJiangping Wu, Jiangping Wu Centre de Recherche du CHUM 1560 Sherbrooke E., Montreal, Qc, H2L 4M1 Canada Department de Medecine, Universite de Montreal and Oncology, McGill University, Montreal, Qc, H2L 4M1 Canada Department of Surgery, McGill University, Montreal, Qc, H2L 4M1 CanadaSearch for more papers by this authorW. Edward C. Bradley, Corresponding Author W. Edward C. Bradley [email protected] Institut du Cancer de Montreal, Montreal, Qc, H2L 4M1 Canada Centre de Recherche du CHUM 1560 Sherbrooke E., Montreal, Qc, H2L 4M1 Canada Department de Medecine, Universite de Montreal and Oncology, McGill University, Montreal, Qc, H2L 4M1 Canada Department of Oncology, McGill University, Montreal, Qc, H2L 4M1 CanadaCorrespondence: Montreal General Hospital Research Institute, Rm. L12–132, 1650 Cedar Ave., Montreal, Canada H3G 1A4. E-mail: [email protected]Search for more papers by this author Andre Toulouse, Andre Toulouse Institut du Cancer de Montreal, Montreal, Qc, H2L 4M1 Canada Centre de Recherche du CHUM 1560 Sherbrooke E., Montreal, Qc, H2L 4M1 CanadaSearch for more papers by this authorMartine Loubeau, Martine Loubeau Centre de Recherche du CHUM 1560 Sherbrooke E., Montreal, Qc, H2L 4M1 CanadaSearch for more papers by this authorJohane Morin, Johane Morin Institut du Cancer de Montreal, Montreal, Qc, H2L 4M1 Canada Centre de Recherche du CHUM 1560 Sherbrooke E., Montreal, Qc, H2L 4M1 CanadaSearch for more papers by this authorJane J. Pappas, Jane J. Pappas Institut du Cancer de Montreal, Montreal, Qc, H2L 4M1 Canada Centre de Recherche du CHUM 1560 Sherbrooke E., Montreal, Qc, H2L 4M1 CanadaSearch for more papers by this authorJiangping Wu, Jiangping Wu Centre de Recherche du CHUM 1560 Sherbrooke E., Montreal, Qc, H2L 4M1 Canada Department de Medecine, Universite de Montreal and Oncology, McGill University, Montreal, Qc, H2L 4M1 Canada Department of Surgery, McGill University, Montreal, Qc, H2L 4M1 CanadaSearch for more papers by this authorW. Edward C. Bradley, Corresponding Author W. Edward C. Bradley [email protected] Institut du Cancer de Montreal, Montreal, Qc, H2L 4M1 Canada Centre de Recherche du CHUM 1560 Sherbrooke E., Montreal, Qc, H2L 4M1 Canada Department de Medecine, Universite de Montreal and Oncology, McGill University, Montreal, Qc, H2L 4M1 Canada Department of Oncology, McGill University, Montreal, Qc, H2L 4M1 CanadaCorrespondence: Montreal General Hospital Research Institute, Rm. L12–132, 1650 Cedar Ave., Montreal, Canada H3G 1A4. E-mail: [email protected]Search for more papers by this author First published: 01 June 2003 https://doi.org/10.1096/fasebj.14.9.1224Citations: 19Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat ABSTRACT The retinoid receptors (RARs and RXRs) are mediators of the multiple effects of retinoic acid. Of these’ the retinoic acid receptor β2 (RARβ2) has frequently been shown to be the principal mediator of the growth and tumor suppressive effects of retinoic acid; this gene is inactivated in many epithelial tumors and their derived cell lines. We have searched for genes that are regulated by this isoform and are potentially involved in tumor suppression. Using the Atlas human cDNA array I, we identified 27 genes (not counting RARβ itself) that are regulated’ directly or indirectly, by RARβ 2 when it is transfected into Calu-1, a lung tumor-derived line that does not normally express RARβ. Several of the affected genes code for proteins whose functions would augment the process of apoptosis and/or the host's immune response. The latter group included ICAM-1 and MHC class I heavy chain, whose protein products play particularly important roles in the mounting of an effective antitumor response. 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