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Synthesis and Biological Evaluation of a Novel Series of 6,8‐ D ibromo‐4(3 H )quinazolinone Derivatives as Anticancer Agents

2013; Wiley; Volume: 346; Issue: 8 Linguagem: Inglês

10.1002/ardp.201300158

1521-4184

Marwa F. Ahmed, Mаhmoud Youns,

Synthesis and Characterization of Heterocyclic Compounds

Three novel series of 6,8‐dibromo‐4(3 H )quinazolinone derivatives were synthesized. Some of the novel quinazolinone derivatives were tested for their antitumor activity against the human breast carcinoma cell line MCF‐7. Compounds XIIIb , IX , XIVd , XIVb , XIVe , XIIIa , XIVc , XVc , and XIVa exerted powerful cytotoxic effects against the MCF7 cells, with very low IC 50 values compared to doxorubicin (positive control). The IC 50 values were 1.7, 1.8, 1.83, 5.4, 6.84, 10.8, 13.9, 15.7, and 29.6 µg/mL, respectively.