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Intraerythrocytic Hemoglobin Crystals in Sickle Cell-Hemoglobin C Disease

1965; Elsevier BV; Volume: 25; Issue: 2 Linguagem: Inglês

10.1182/blood.v25.2.218.218

1528-0020

L. W. Diggs, Ann Bell,

Blood groups and transfusion

Abstract On 70 per cent of the blood smears from 60 cases of electrophoretically proven sickle cell-hemoglobin C disease, there is observed a misshapen erythrocyte that contains condensed hemoglobin crystals which are dark-hued, homogeneous and elongated and which have parallel sides with one end terminating in a pyramid or rounded shape. A red blood corpuscle may have multiple protuberances at varying angles to each other. The incidence of intracellular hemoglobin crystals was found to be 0-24 per 1000 red blood cells with an average of 3.2/1000. Recognition of this unusual morphology is presumptive evidence of sickle cell-hemoglobin C and warrants examination by electrophoretic procedures.