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Correlated gene expression supports synchronous activity in brain networks

2015; American Association for the Advancement of Science; Volume: 348; Issue: 6240 Linguagem: Inglês

10.1126/science.1255905

1095-9203

Jonas Richiardi, André Altmann, Anna-Clare Milazzo, Catie Chang, M. Mallar Chakravarty, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Patricia Conrod, Mira Fauth‐Bühler, Herta Flor, Vincent Frouin, Jürgen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Hervé Lemaître, Karl Mann, Jean‐Luc Martinot, Frauke Nees, Tomáš Paus, Zdenka Pausová, Marcella Rietschel, Trevor W. Robbins, Michael N. Smolka, Rainer Spanagel, Andreas Ströhle, Günter Schumann, Mike Hawrylycz, Jean‐Baptiste Poline, Michael D. Greicius, Lisa Albrecht, Chris Andrew, Mercedes Arroyo, Éric Artiges, Semiha Aydın, Christine Bach, Tobias Banaschewski, Alexis Barbot, Gareth J. Barker, Nathalie Boddaert, Arun L.W. Bokde, Zuleima Bricaud, Uli Bromberg, Ruediger Bruehl, Christian Büchel, Arnaud Cachia, Anna Cattrell, Patricia Conrod, Patrick Constant, Jeffrey W. Dalley, Benjamin Decideur, Sylvane Desrivières, Tahmine Fadai, Herta Flor, Vincent Frouin, Jürgen Gallinat, Hugh Garavan, Fanny Gollier Briand, Penny Gowland, Bert Heinrichs, Andreas Heinz, Nadja Heym, Thomas Hübner, James J. Ireland, Bernd Ittermann, Tianye Jia, Mark Lathrop, Dirk Lanzerath, Claire Lawrence, Hervé Lemaître, Katharina Lüdemann, Christine Macare, Catherine Mallik, Jean‐François Mangin, Karl Mann, Jean- Luc Martinot, Eva Mennigen, Fabiana Mesquita de Carvahlo, Xavier Mignon, Rubén Miranda, Kathrin Müller, Frauke Nees, Charlotte Nymberg, Marie-Laure Paillère, Tomáš Paus, Zdenka Pausová, Jean‐Baptiste Poline, Luise Poustka, Michael A. Rapp, Guillaume Robert, J.H. Reuter, Marcella Rietschel, Stephan Ripke, Trevor W. Robbins, Sarah Rodehacke, John Rogers, Alexander Romanowski, Barbara Ruggeri, Christine Schmäl, Dirk Schmidt, Sophia Schneider, MarkGunter Schumann, Herta Flor, Yannick Schwartz, Michael N. Smolka, Wolfgang H. Sommer, Rainer Spanagel, Claudia Speiser, Tade Matthias Spranger, Alicia Stedman, Sabina Steiner, D.N. Stephens, Nicole Strache, Andreas Ströhle, Maren Struve, Naresh Subramaniam, Lauren Topper, Robert Whelan, Steven Williams, Juliana Yacubian, Mônica Zilbovicius, Cybele P. Wong, Steven Lubbe, Lourdes Martinez-Medina, Alinda R. Fernandes, Amir Tahmasebi,

Advanced MRI Techniques and Applications

During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, the molecular mechanisms supporting functional connectivity remain undefined. We show that functional brain networks defined with resting-state functional magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem brain tissue data set. The set of 136 genes we identify is significantly enriched for ion channels. Polymorphisms in this set of genes significantly affect resting-state functional connectivity in a large sample of healthy adolescents. Expression levels of these genes are also significantly associated with axonal connectivity in the mouse. The results provide convergent, multimodal evidence that resting-state functional networks correlate with the orchestrated activity of dozens of genes linked to ion channel activity and synaptic function.