The Synthesis of N,N ‐Bis(dialkoxyphosphinoylmethyl)‐ and N,N ‐Bis(diphenylphosphinoylmethyl)glycine Esters by the Microwave‐Assisted Double Kabachnik–Fields Reaction
2013; Wiley; Volume: 24; Issue: 6 Linguagem: Inglês
10.1002/hc.21126
ISSN1098-1071
AutoresErika Bálint, Eszter Fazekas, László Drahos, György Keglevich,
Tópico(s)Asymmetric Hydrogenation and Catalysis
ResumoABSTRACT The condensation of a glycine ester, two equivalents of paraformaldehyde, and the same quantity of a dialkyl phosphite or diphenylphosphine oxide afforded the title compounds as new bis(phospha‐Mannich) products under microwave (MW) conditions at 100°C. The dialkoxyphosphinoylmethyl derivatives were synthesized under solvent‐free conditions, whereas the diphenylphosphinoylmethyl derivatives were synthesized in acetonitrile solution. Comparative thermal experiments showed the beneficial role of MW in respect of efficiency.
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