(B) Mechanisms of peptide and protein absorption
1991; Elsevier BV; Volume: 7; Issue: 3 Linguagem: Inglês
10.1016/0169-409x(91)90014-4
ISSN1872-8294
AutoresPhilip S. Burton, Robert A. Conradi, Allen R. Hilgers,
Tópico(s)DNA and Nucleic Acid Chemistry
ResumoA major factor contributing to the poor bioavailability of peptides and proteins after non-parenteral administration is thought to be inefficient transport across cellular barriers. While the transport barrier for less functionalized drugs has been successfully modeled as a homogeneous octanol-like phase, peptide transport results do not fit this model. In this article we reexamine the literature on peptide transport, the architecture of biological membranes and peptide-lipid interactions. Based on these considerations, it is suggested that more realistic models, which incorporate the non-homogeneous nature of real biological membranes, provide a better basis for understanding the transport potential of highly functionalized molecules such as peptides and proteins.
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