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Regulation of Pentitol Metabolism by Aerobacter aerogenes I. Coordinate Control of Ribitol Dehydrogenase and d -Ribulokinase Activities

1968; American Society for Microbiology; Volume: 95; Issue: 3 Linguagem: Inglês

10.1128/jb.95.3.925-931.1968

1098-5530

Theresa M. Bisson, Robert P. Mortlock,

Enzyme Structure and Function

Induction studies on Aerobacter aerogenes strain PRL-R3, using ribitol as the inducer-substrate, indicated that two enzymes of ribitol catabolism, ribitol dehydrogenase and d -ribulokinase, are coordinately induced. The utilization of d -arabinose as a substrate resulted in the induction of ribitol dehydrogenase as well as d -ribulokinase. Mutants which were constitutive for ribitol dehydrogenase were also constitutive for d -ribulokinase. In contrast, d -xylulokinase and d -arabitol dehydrogenase did not appear to be coordinately controlled. Induction studies and examination of d -arabitol dehydrogenase constitutive mutants indicated that the three enzymes of the converging pathways for d -arabitol and d -xylose catabolism are under separate control.