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BIBTEX RIS

Antinociceptive and antiinflammatory activities of the aqueous extract and isolated Cuphea carthagenensis (Jacq.) J. F. Macbr.

2002; Springer Science+Business Media; Volume: 12; Linguagem: Inglês

10.1590/s0102-695x2002000300027

ISSN

1981-528X

Autores

Francis Rigolo Fernandes, André Luís dos Santos, Ana Maria Soares de Arruda, Luciana de Miranda C. Vasques-Pinto, Rosely Oliveira Godinho, Luce Maria Brandão Torres, Antônio José Lapa, Caden Souccar,

Tópico(s)

Natural Compound Pharmacology Studies

Resumo

The aqueous extract (AE) and isolated fraction (ppt-3) of Cuphea carthagenensis (Jacq.) J. F. Macbr (sete-sangrias) were tested using models of nociception and inflammation in mice. Oral administration (p.o.) of the AE (10 to 100 mg/kg) and fraction ppt-3 (0.1 to 10 mg/kg) reduced the acetic acid-induced writhing in mice by 40 to 50% and by 46 to 70% of control, respectively. At the same doses AE and ppt-3 did not affect the tail flick response. Fraction ppt-3 also reduced the carrageenininduced paw edema, but at a dose 1000 times higher than that inducing antinociception. The results indicated the presence in the plant of antinociceptive constituents devoid of antiinflammatory activity, with actions apparently mediated by non-opioid mechanisms.

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