LIVER FUNCTION AND SERUM PROTEIN STRUCTURE IN GOUT
1949; American College of Physicians; Volume: 30; Issue: 3 Linguagem: Inglês
10.7326/0003-4819-30-3-598
ISSN1539-3704
Autores Tópico(s)Porphyrin Metabolism and Disorders
ResumoArticle1 March 1949LIVER FUNCTION AND SERUM PROTEIN STRUCTURE IN GOUTW. Q. WOLFSON, M.D., C. COHN, M.D., R. LEVINE, M.D., E. F. ROSENBERG, M.D., F.A.C.P., H. D. HUNT, M.D.W. Q. WOLFSON, M.D., C. COHN, M.D., R. LEVINE, M.D., E. F. ROSENBERG, M.D., F.A.C.P., H. D. HUNT, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-3-598 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe medical literature of the past century contains numerous references to the supposed rôle of the liver in gout.7 through 15, 23, 24, 30, 31, 42, 50, 55, 62, 63, 79Three types of hypothesis have been presented: (1) that gout results from an isolated disturbance in some hepatic enzyme, (2) that gout results from chronic diffuse hepatic impairment, and (3) that hepatic impairment is a frequent visceral complication of gout. The first hypothesis is as yet difficult to evaluate, since suitable methods of study have only recently become available.31, 32, 33The latter two hypotheses may be evaluated by...Bibliography1. LOEB RF: Plasma proteins in health and disease, New Eng. Jr. Med., 1941, ccxxiv, 980. CrossrefGoogle Scholar2. BOYD WC: Fundamentals of Immunology, 2nd Ed., 1947, Interscience Publishers, New York. Google Scholar3. FICARRAADAMS BJR: Postoperative gouty arthritis, Arch. Surg., 1945, l, 229. CrossrefGoogle Scholar4. FICARRA BJ: Significance of hyperuricemia in surgery, Am. Jr. Surg., 1947, lxxiii, 363. CrossrefGoogle Scholar5. WOLFSONCOHNCALVARYICHIBA WQCEF: Studies in serum proteins. V. A rapid procedure for the estimation of total protein, true albumin, total globulin, alpha globulin, beta globulin and gamma globulin in 1.0 ml. of serum, Am. Jr. Clin. Path., 1948, xviii, 723. CrossrefGoogle Scholar6. WOLFSONCOHNCALVARYTHOMAS WQCEEM: Studies in serum proteins. IV. Clinical studies employing rapid chemical fractionation procedures, with particular reference to the frequency and significance of hypoalbuminemia, Jr. Lab. and Clin. Med., 1948, xxxiii, 1276. Google Scholar7. PRINGLE GL: Treatment of some errors of metabolism at bath, British Med. Jr., 1937, i, 1017. CrossrefGoogle Scholar8. FREUND E: The importance of biochemistry in the investigation of rheumatic diseases in A Survey of Chronic Rheumatic Disease, 1938, Oxford University Press, New York, pp. 227-239. Google Scholar9. MJASSNIKOW AL: Beiträge zur Konstitutionsforschung: Blutcholesteringehalt und Konstitution, Ztschr. f. klin. Med., 1927, cv, 228. Google Scholar10. KAUFTHEIL L: Ueber den Cholesteringehalt des Blutserums bei Gelenkerkrankungen, Wien. Arch. f. klin. Med., 1929, xix, 273. Google Scholar11. CHAUFFARD A: Le syndrome humoral de la goutte, Presse med., 1922, xxx, 253. Google Scholar12. CHAUFFARDTROISIER AJ: Goutte et cholesterine, Ann. de med., 1921, ix, 149. Google Scholar13. FINCK CJ: De la pathogenie de la goutte, Paris med., 1935, ii, 336. Google Scholar14. DE FOSSEY AM: Phenomenes morbides latents. Role de la constitution et du temprament envisages par la morphologie et les constantes chimiques, Nutrition, 1938, vii, 377. Google Scholar15. DE FOSSEY AM: Traitement hydromineral de la goutte abarticulaire. Syndrome hepatodigestif, 1939, L'Expansion Scientifique, Paris, Francaise. Google Scholar16. SCHOENHEIMERSPERRY RWM: A micromethod for the determination of free and combined cholesterol, Jr. Biol. Chem., 1934, cvi, 745. CrossrefGoogle Scholar17. SPERRY WM: The concentration of total cholesterol in the blood serum, Jr. Biol. Chem., 1937, cxvii, 391. CrossrefGoogle Scholar18. PETERSVAN SLYKE JPDD: Quantitative Clinical Chemistry, 2nd ed., 1946, Interpretations, Volume I. The Williams and Wilkins Company, Baltimore. Google Scholar19. SELYE H: The general adaptation syndrome and the diseases of adaptation, Jr. Clin. Endocrin., 1946, vi, 117. CrossrefGoogle Scholar20. WHITEDOUGHERTY ATP: The role of lymphocytes in normal and immune globulin production and the mode of release of globulin from lymphocytes, Ann. N. Y. Acad. Sci., 1946, xlvi, 859. CrossrefGoogle Scholar21. WHITEDOUGHERTY ATP: Role of the adrenal cortex and the thyroid in the mobilization of nitrogen from the tissues in fasting, Endocrinology, 1947, xli, 230. CrossrefGoogle Scholar22. MANNSNELLBUTT FDAMHR: The thymol turbidity test and impaired liver function, Gastroenterology, 1947, ix, 651. Google Scholar23. CHROMETZKA F: Der Purinstoffwechsel des Menschen, Ergeb. inn. Med. u. Kinderh., 1932, xliv, 538. Google Scholar24. CHROMETZKA F: Die zentrale Stellung der Leber im Purinstoffwechsel und ihre Bedeutung für die Pathogenese der Gicht, Klin. Wchnschr., 1936, xv, 1877. CrossrefGoogle Scholar25. LEWIS HB: End products of nitrogen metabolism in animals, Biol. Symp., 1941, v, 20. Google Scholar26. RHEINBERGER MB: The nitrogen partition in the urine of various primates, Jr. Biol. Chem., 1936, cxv, 343. CrossrefGoogle Scholar27. RABINOWITCH IM: Biochemical findings in a rare case of acute yellow atrophy of the liver, Jr. Biol. Chem., 1929, lxxxiii, 333. CrossrefGoogle Scholar28. TAUBER H: Absence of blood uric acid in a case of liver damage, Jr. Am. Inst. Homeopath., 1931, xxiv, 515. Google Scholar29. MORGAN EJ: Distribution of xanthine oxidase, Biochem. Jr., 1926, xx, 1282. CrossrefGoogle Scholar30. DE BERSAQUESBERAT A: Hyperuremie et hyperuricemie chez les hepatiques, Jr. Belge Gastro-Enterol., 1936, vi, 28. Google Scholar31. GRAYFELSHER SJRZ: Studies on the inhibition of xanthine oxidase, Proc. Soc. Exper. Biol. and Med., 1945, lix, 287. CrossrefGoogle Scholar32. KEESER E: Untersuchungen über die Beeinflussbarkeit des Purinstoffwechsels, Arch. f. exper. Path. u. Pharm., 1941, cxcvii, 187. Google Scholar33. WOLFSONCOHNKADOTA WQCK: Oxypurine metabolism in man: preliminary report, Fed. Proc. In press. Google Scholar34. GALLINOWSKY Z: Le metabolisme purique dans les affections due parenchyme hepatique, Bull. Internat. Acad. Polon. de Sci. et de Lett. (Cl. Med.), 1935, clxxxi. Google Scholar35. GALLINOWSKY Z: Badnia nad Przemiana Purynowa W Chorobach Miasszu Watrbowego, Pol. Arch. n. Biolog. i Lek., 1935, xiii, 278. Google Scholar36. JIMINEZ-DIAZMOGENA JH: Estudios de insufficienca hepatica: El metabolismo del acido urico en los enfermadades del higado, Ann. de med. int., 1932, i, 507. Google Scholar37. ROBECCHIMUTTINI AC: Studi sul metabolismo purinico. Il ricambio purinico negli epatopazienti, Arch. per le sc. med., 1938, lxv, 475. Google Scholar38. LUCKE H: Die enterotropische Harnsäure, Ztschr. f. d. ges. exper. Med., 1931, lxxvi, 188. CrossrefGoogle Scholar39. KÜRTI L: Untersuchungen über den Harnsäurestoffwechsel bei Nierenkranken, Ztschr. f. klin. Med., 1932, cxxii, 585. Google Scholar40. KÜRTI L: Die Wirkung des Atophans auf die enterotrope Harnsäureausscheidung, Klin. Wchnschr., 1929, ii, 2239. CrossrefGoogle Scholar41. LUCKE H: Das Harnsäureproblem und seine klinische Bedeutung, Ergeb. inn. Med. u. Kinderh., 1932, xliv, 499. Google Scholar42. ROBECCHIPESCARMONA AM: Studi sul metabolismo purinico. Le alterazione del fegato nei gottosi, Arch. per le sc. med., 1938, lxv, 875. Google Scholar43. BRØCHNER-MORTENSEN K: One hundred gouty patients, Acta med. Scandinav., 1941, cvi, 81. Google Scholar44. RONAPETOWSCHREIBER PHH: Eine Methode zum Nachweis Blutfremder Fermente im Serum, Klin. Wchnschr., 1922, i, 2366. CrossrefGoogle Scholar45. MCCRACKENOWENPRATT JHPSJH: Gout: still a forgotten disease, Jr. Am. Med. Assoc., 1946, cxxxi, 367. CrossrefGoogle Scholar46. Case Records of the Massachusetts General Hospital, Case No. 32222, New Eng. Jr. Med., 1946, ccxxxiv, 741. Google Scholar47. AREYPETERSON JBWE: Presentation of a case, Minnesota Med., 1944, xxvii, 644. Google Scholar48. LAMBIEDAVIES CGGF: A case of chronic gout with anemia, Med. Jr. Australia, 1941, i, 701. CrossrefGoogle Scholar49. Case Records of the Massachusetts General Hospital, Case No. 27361, New Eng. Jr. Med., 1941, ccxxv, 382. Google Scholar50. EDGECOMBE W: The metabolic and endocrine background of arthritis in A Survey of Chronic Rheumatic Disease, 1938, Oxford University Press, New York, pp. 63-71. Google Scholar51. DE BONIS G: Il ricambio glicido nelle gotta e nelle sindromi paragottose, Fisiolog. E Med., 1940, xi, 1. Google Scholar52. STEINBERGLOWENSTEIN CLFW: The Weltmann reaction in arthritis, Am. Jr. Clin. Path., 1945, xv, 395. CrossrefGoogle Scholar53. MILESSALT HLHB: A study of certain blood tests which reveal colloidal abnormalities in rheumatic conditions, Ann. Rheumat. Dis., 1941, ii, 192. CrossrefGoogle Scholar53a. WUHRMANNWUNDERLY FC: Die Bluteiweisskörper des Menschen, 1947, Benno Schwabe and Company, Basel. Google Scholar54. COKE H: Gout, biochemical aspects, Rheumatism, 1946, iii, 53. Google Scholar55. BURTGORDON JBRG: Gout, an unsolved problem, Ann. Rheumat. Dis., 1939, i, 304. CrossrefGoogle Scholar56. FITZ R: Three cases of intermittently painful joints, splenomegaly, and anemia, Med. Clin. North Am., 1935, xviii, 1053. Google Scholar57. OPSAHL R: Hematopoiesis and endogenous uric acid, Acta med. Scandinav., 1939, cii, 611. Google Scholar58. SEARS WG: Occurrence of gout during the treatment of pernicious anemia, Lancet, 1933, i, 24. CrossrefGoogle Scholar59. HERRICKTYSON WWTL: Gout: a forgotten disease, Am. Jr. Med. Sci., 1936, cxcii, 483. CrossrefGoogle Scholar60. DEITRICK JE: The association of congenital hemolytic icterus and gout, Internat. Clin., 1940, iii, 264. Google Scholar61. KRAFKA J: Neglected factor in the etiology of gout, Jr. Bone and Joint Surg., 1935, xvii, 1049. Google Scholar62. GRAFE E: Gout in Metabolic Diseases and Their Treatment, 1933, Lea and Febiger, Philadelphia. Google Scholar63. LICHTWITZ L: Functional Pathology, 1941, Grune and Stratton, New York. Google Scholar64. TALBOTT JH: Gout, 1943, Oxford University Press, New York. Google Scholar65. SCULLBACHPEMBERTON CWTFR: Serum proteins in rheumatoid disease, Ann. Int. Med., 1939, xii, 1463. Google Scholar66. ALDRED-BROWNMUNRO GRJM: The plasma proteins and non-protein nitrogen and the sedimentation rate in chronic rheumatic disorders, Quart. Jr. Med., 1935, iv, 269. Google Scholar67. MESTER AJ: Blood plasma fibrinogen in rheumatic and non-rheumatic conditions, Ann. Rheumat. Dis., 1945, iv, 57. CrossrefGoogle Scholar68. WEILPOLAK MPC: Le rheumatisme goutteux, Presse med., 1936, i, 26. Google Scholar69. LUDWIGBENNETTBAUER AOGAW: A rare manifestation of gout: widespread ankylosis simulating rheumatoid arthritis, Ann. Int. Med., 1938, xi, 1248. LinkGoogle Scholar70. VININGTHOMAS CWJG: Gout and aleukemic leukemia in a boy aged 5, Arch. Dis. Child., 1934, ix, 277. CrossrefGoogle Scholar71. PERLMANKAUFMAN GED: Electrophoretic distribution of proteins in serum, plasma, and synovial fluid of patients with rheumatoid arthritis, Jr. Clin. Invest., 1946, xxv, 931. Google Scholar72. DOLEROTHBARD VPS: Electrophoretic changes in the serum of a patient with rheumatoid arthritis, Jr. Clin. Invest., 1947, xxvi, 87. CrossrefGoogle Scholar73. OLHAGEN B: Om Electroforese Diagram pa Plasma fran Homo vid Patologiske Tillstand, Nord. med., 1944, xxiii, 1530. Google Scholar74. LÖVGREN O: Studien über den intermediären Stoffwechsel bei chronischer Polyarthritis, Acta med. Scandinav., 1945, clxiii, 1. Google Scholar75. MALMROSBLIX HG: The plasma proteins in cases with high erythrocyte sedimentation rate, Acta med. Scandinav., 1946, clxx, 1. Google Scholar76. JAGER BV: Treatment of rheumatoid arthritis with massive doses of salicylates, with particular reference to modification of plasma protein constituents during therapy, Am. Jr. Med., 1946, ii, 665. Google Scholar77. SPARKESHADEN MIRL: The blood volume in chronic arthritis, Am. Jr. Med. Sci., 1932, clxxxiv, 753. Google Scholar78. ROBINSON GL: A study of liver function and plasma volume in chronic rheumatism by means of phenol-tetrabrom-phthalein sodium sulphonate, Ann. Rheumat. Dis., 1943, iii, 1. Google Scholar79. COWANHARKNESS ICJ: The plasma viscosity in rheumatic diseases, Brit. Med. Jr., 1947, ii, 686. CrossrefGoogle Scholar80. CARTERMACLAGAN ABNF: Some observations on liver function tests in diseases not primarily hepatic, Brit. Med. Jr., 1946, ii, 80. CrossrefGoogle Scholar81. DAVIS JS: The possible role of the liver in rheumatoid arthritis and gout, Surgo (University of Edinburgh), 1943, x, 3. Google Scholar82. GIBSONRICHARDSON HJEW: The formol-gel test (aldehyde reaction) in chronic rheumatism, Acta Rheumat., 1938, x, 1. Google Scholar83. GIBSONPITT HJRM: The formol-gel test on plasma and serum in rheumatic cases, Ann. Rheumat. Dis., 1946, v, 83. CrossrefGoogle Scholar84. COMROE BI: Arthritis and Allied Conditions, 1944, Lea and Febiger, Philadelphia. Google Scholar85. RACE J, quoted by Edgecombe.50 Google Scholar86. WALLIS AD: Rheumatoid arthritis. I. Introduction to a study of its pathogenesis, Am. Jr. Med. Sci., 1946, ccxii, 713. CrossrefGoogle Scholar87. WALLIS AD: Rheumatoid arthritis. III. The pneumococcus antibodies, Am. Jr. Med. Sci., 1946, ccxii, 718. CrossrefGoogle Scholar88. WALLIS AD: Rheumatoid arthritis. IV. Hemolytic streptococcus precipitin reactions, Am. Jr. Med. Sci., 1947, ccxiii, 87. CrossrefGoogle Scholar89. WALLIS AD: Rheumatoid arthritis. V. The agglutination of hemolytic streptococci, Am. Jr. Med. Sci., 1947, ccxiii, 94. CrossrefGoogle Scholar90. WATSONLERNER CJAB: The clinical significance of cryoglobulinemia, Acta med. Scandinav., 1947, cxcvi, 489. Google Scholar91. TALKOVBAUERSHORT RHWCL: Rheumatoid arthritis associated with splenomegaly and leukopenia, New Eng. Jr. Med., 1942, ccxxvii, 395. CrossrefGoogle Scholar92. Case Records of the Massachusetts General Hospital, Case No. 31212, New Eng. Jr. Med., 1945, ccxxxii, 632. Google Scholar93. FINGERMANANDRUS DLFC: Visceral lesions associated with rheumatoid arthritis, Ann. Rheumat. Dis., 1943, iii, 168. CrossrefGoogle Scholar94. HEPBURNWARTERROSENSTEIN JSPJG: Liver function in arthritis, measured by the hippuric acid test, Rev. Gastroenterol., 1943, x, 126. Google Scholar95. RAWLSWEISSCOLLINS WBSVL: Liver function in rheumatoid arthritis, Ann. Int. Med., 1939, xii, 1455. Google Scholar96. HUEPER WC: Cinchophen (atophan). A critical review, Medicine, 1948, xxvii, 434. Google Scholar97. LONG CN: The conditions associated with the secretion of the adrenal cortex, Fed. Proc., 1947, vi, 461. Google Scholar98. MASONPOWERRYNEARSONCIARAMELLILIEVANS HLMHEHLCCHHM: Results of administration of anterior pituitary adrenocorticotropic hormone to a normal human subject, Jr. Clin. Endocrin., 1948, viii, 1. CrossrefGoogle Scholar99. KELLEYADAMS VCJM: Blood chemical and immunologic effects of adrenal cortical extract in children, Jr. Pediat., 1948, xxxii, 282. CrossrefGoogle Scholar100. WOLFSONCOHNLEVINE WQCR: Serum cholesterol changes during the gout cycle. In preparation. Google Scholar100. WOLFSONCOHNROSENBERG WQCEF: Serum cholesterol changes during the gout cycle. In preparation. Google Scholar101. TEPPERMANTEPPERMANPATTONNIMS JHMBWLF: Effects of low barometric pressure on the chemical composition of the adrenal glands and blood of rats, Endocrinology, 1947, xli, 356. CrossrefGoogle Scholar102. FORSHAMTHORNPRUNTYHILLS PHGWFTAG: Clinical studies with pituitary adrenocorticotropin, Jr. Clin. Endocrin., 1948, viii, 15. CrossrefGoogle Scholar103. HELLMANWESTONESCHERLEITER LREDJL: The effect of adrenocorticotropins on renal hemodynamics and uric acid clearance, Fed. Proc., 1948, vii, 52. Google Scholar104. FOLINBERGLUNDDERICK OHC: The uric acid problem, Jr. Biol. Chem., 1924, lx, 36. Google Scholar105. FUTCHER TB: Some points on metabolism in gout: with special reference to the relationships between the uric-acid and the phosphoric-acid elimination in the intervals and during acute attacks, The Practitioner, August, 1903. Google Scholar106. LÖFFLERKOLLER WF: Die Gicht, Handb. d. inn. Med., 1944, vi, 855. Google Scholar107. TALBOTTJACOBSONOBERG JHBMSA: The electrolyte balance in acute gout, Jr. Clin. Invest., 1935, xiv, 411. CrossrefGoogle Scholar108. ROBINSONCONNBLOCKLOUIS WDJWWDLH: Role of the adrenal cortex in urate metabolism and in gout, Proc. Cen. Soc. Clin. Res., 1948, xxi, 23. Google Scholar109. LEITER L: Discussion of presentation by Robinson et al.,108 Central Society for Clinical Research, Chicago, October 30, 1948. Google Scholar110. FRASER TN: Flocculation tests in rheumatoid arthritis, Ann. Rheumat. Dis., 1948, vii, 83. CrossrefGoogle Scholar111. ROSERAGANPEARCELIPMAN HMCEMO: Differential agglutination of normal and sensitized sheep erythrocytes by sera of patients with rheumatoid arthritis, Proc. Soc. Exper. Biol. and Med., 1948, lxviii, 1. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: W. Q. WOLFSON, M.D.; C. COHN, M.D.; R. LEVINE, M.D.; E. F. ROSENBERG, M.D., F.A.C.P.; H. D. HUNT, M.D.*Received for publication July 3, 1948.From the Department of Biochemistry,† and the Department of Metabolic and Endocrine Research,† Medical Research Institute, Michael Reese Hospital; the Division of Medicine and the Arthritis Clinic, Michael Reese Hospital, Chicago; and the Department of Internal Medicine, Albany Medical College.†Aided by a grant from the Committee on Scientific Research of the American Medical Association. These Departments are also in part supported by the Michael Reese Research Foundation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHE ROLE OF HORMONES IN THE PATHOGENESIS AND TREATMENT OF GOUTHyperuricemia in Health and DiseaseIdiopathic Hyperlipemia and GoutEssential HypercholesterolemiaEssential HyperlipemiaHypertriglyceridemia in GoutDie GichtRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., EDWARD W. BOLAND, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., WALLACE GRAHAM, M.D., F.R.C.P. (C), L. MAXWELL LOCKIE, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D.Gout: An Unusual Case with Softening and Subluxation of the First Cervical Vertebra and Splenomegaly Result of Acth Administration and Eventual Post-Mortem Findings 1 March 1949Volume 30, Issue 3 Page: 598-614 Keywords Arthritis Enzymes Gout Hospital medicine Liver Serum proteins ePublished: 1 December 2008 Issue Published: 1 March 1949 PDF downloadLoading ...
Referência(s)