Membrane Protein Insertion and Stability
2005; American Association for the Advancement of Science; Volume: 307; Issue: 5714 Linguagem: Inglês
10.1126/science.1110525
ISSN1095-9203
Autores Tópico(s)Cellular transport and secretion
ResumoThe translocon is an endoplasmic reticulum membrane protein that has the dual ability to insert a newly synthesized polypeptide chain into a cell membrane or secrete it across a cell membrane. This process has been exploited to assess the energetics of transmembrane-helices, as described in two recent studies by the von Heijne and White groups (published here and elsewhere). In a Perspective, MacKinnon discusses the implications of this work for membrane protein structure and function.
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