Portal de Periódicos da CAPES

FAMILIAL HODGKIN'S DISEASE: ITS SIGNIFICANCE AND IMPLICATIONS

1959; American College of Physicians; Volume: 51; Issue: 5 Linguagem: Inglês

10.7326/0003-4819-51-5-933

1539-3704

Dennis V. Razis, Henry D. Diamond, L F CRAVER,

Chronic Lymphocytic Leukemia Research

Article1 November 1959FAMILIAL HODGKIN'S DISEASE: ITS SIGNIFICANCE AND IMPLICATIONSDENNIS V. RAZIS, M.D., HENRY D. DIAMOND, M.D., F.A.C.P., LLOYD F. CRAVER, M.D., F.A.C.P.DENNIS V. RAZIS, M.D.Search for more papers by this author, HENRY D. DIAMOND, M.D., F.A.C.P.Search for more papers by this author, LLOYD F. CRAVER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-5-933 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTION"When you can measure what you are speaking about, and express it in numbers, you know something about it, but when you cannot measure it, when you cannot express it in numbers, your knowledge is of a meager and unsatisfactory kind."—Lord KelvinFamilial concentration of any given disease may occur as a mere coincidence. This must be emphasized if one is not to be misled by individual pedigrees with a high incidence of a particular disease. With this in mind, it is apparent that we do not know whether the reported cases of familial Hodgkin's disease in the medical...Bibliography1. MacDonald EJ: Historical trends in cancer, in Cancer. A manual for practitioners, 3rd Ed., 1956, American Cancer Society (Massachusetts Division), Inc., Boston, p. 1. Google Scholar2. Gorer PA: Cancer, in Clinical genetics, edited by Sorsby, A., 1953, C. V. Mosby Co., St. Louis, p. 558. Google Scholar3. Brobeck O: Heredity in cancer uteri: a genetical and clinical study of 200 patients with cancer of the cervix uteri and 90 patients with cancer of the corpus uteri, 1949, Universitets forloget, Aarhus, Denmark. Google Scholar4. Jacobsen O: Heredity in breast cancer: a genetic and clinical study of 200 probands, 1946, H. K. Lewis & Co., Ltd., London. Google Scholar5. Murphy DP: Heredity in uterine cancer, 1952, Harvard University Press, Cambridge. Google Scholar6. Videbaek A: Familial leukemia. A preliminary report, Acta med. Scandinav. 127: 26, 1947. CrossrefGoogle Scholar7. Videbaek A: Heredity in human leukemia and its relation to cancer, 1947, H. K. Lewis & Co., Ltd., London. Google Scholar8. Macklin MT: The role of heredity in gastric and intestinal cancer, Gastroenterology 29: 507, 1955. CrossrefMedlineGoogle Scholar9. Busk T: Genetical studies in leukemia, 1952, Proceedings of the 2nd National Cancer Conference, American Cancer Society, New York, p. 1087. Google Scholar10. ClemmensenSorensen JJ: Malignant neoplasms of haemopoietic and connective tissues in various countries. Cancer incidence in Denmark 1943 to 1953 V, Danish M. Bull. 5: 73, 1958. MedlineGoogle Scholar11. Gorer PA, in a review of Videbaek, Ann. Eugenics 14: 346, 1949. Google Scholar12. VidebaekMosbech AJ: The aetiology of gastric carcinoma elucidated by a study of 302 pedigrees, Acta med. Scandinav. 149: 137, 1954. CrossrefMedlineGoogle Scholar13. Kaplan II: Carcinoma of the breast in one of homologous twin sisters, Am. J. M. Sc. 190: 331, 1935. CrossrefGoogle Scholar14. McFarlandMeade JTS: The genetic origin of tumors, supported by their simultaneous and symmetrical occurrence in homologous twins, Am. J. M. Sc. 184: 66, 1932. CrossrefGoogle Scholar15. Macklin MT: An analysis of tumors in monozygous and dizygous twins. Report of 15 unpublished cases, J. Hered. 31: 277, 1940. CrossrefGoogle Scholar16. PeyronKobozieff AN: Les tumeurs chez les jumeaux, Bull. Assoc. franç. p. l'étude du cancer 26: 93, 1937. Google Scholar17. Dunn LC: Genetics in the 20th Century, 1951, The Macmillan Co., New York. Google Scholar18. Macklin MT: Heredity and constitution in disease, in Pathology, 3rd Ed., Chapter 45, Edited by Anderson, W. A., 1957, The C. V. Mosby Co., St. Louis. Google Scholar19. Stern C: Principles of human genetics, 1949, W. H. Freeman & Co., San Francisco. Google Scholar20. Peacocke G: Hodgkin's disease occurring in twins, Dublin J. M. Sc. 120: 85, 1905. CrossrefGoogle Scholar21. Remde W: Uber konkordantes Auftreten von Lymphogranulomatose bei einigen Zwillingen, Innere Med. 5: 15, 1950. Google Scholar22. Charache H: Tumors in one of homologous twins. Hodgkin's disease, osteogenic sarcoma, Am. J. Roentgenol. 46: 69, 1941. Google Scholar23. Charache H: Tumors in one of homologous twins. Hodgkin's disease with primary skeletal manifestations, Am. J. Roentgenol. 54: 179, 1945. Google Scholar24. Charache H: Hodgkin's disease in children, New York State J. Med. 46: 507, 1946. MedlineGoogle Scholar25. HosterDratman HAMB, edited by Craver, L. F., and Rolnick, H. A.: Hodgkin's disease, 1832-1947, Cancer Research 8: 1, 1948. MedlineGoogle Scholar26. AllanBlacklock GAJW: Hodgkin's disease with paraplegia, Glasgow M. J. 103: 115, 1925, cited by Wallhauser, A.: Hodgkin's disease, Arch. Path. 16: 522, 1933; 16: 672, 1933. MedlineGoogle Scholar27. Arkin A: Familial mediastinal lymphogranuloma, Am. J. M. Sc. 171: 669, 1926. CrossrefGoogle Scholar28. Bonati F: Clinical and statistical findings in Hodgkin's disease, Gior. di clin. med. 31: 746, 1950. MedlineGoogle Scholar29. Branch CF: A case of congenital lymphoblastoma, Am. J. Path. 9: 777, 1933. MedlineGoogle Scholar30. Brennan MJ: Personal communication to DeVore, J. W., and Doan, C. A.38 Google Scholar31. BuntingYates CHJA: An etiologic study of Hodgkin's disease—preliminary note, J. A. M. A. 61: 1803, 1913. CrossrefGoogle Scholar32. Burnam CF: Hodgkin's disease with special reference to its treatment by irradiation, J. A. M. A. 87: 1445, 1926. CrossrefGoogle Scholar33. Chiari H: Personal communication to Mallory, G. K., cited by Branch, C. F.29 Google Scholar34. Davis PL: Personal communication to Mazar, S. A., and Strauss, B.50 Google Scholar35. DeCandia S: Morbo di Hodgkin familiare, Clin. nuova 2: 234, 1936. Google Scholar36. Degen H: Ein Beitrag zur Lehre vom Lymphosarcom, Inaug. Diss., 1886, S. Abel, Greifswald, cited by Arkin, A.27 Google Scholar37. Desjardins AV: The etiology of lymphoblastoma, J. A. M. A. 103: 1033, 1934. CrossrefGoogle Scholar38. DeVoreDoan JWCA: Studies in Hodgkin's syndrome. XII. Hereditary and epidemiological aspects, Ann. Int. Med. 47: 300, 1957. LinkGoogle Scholar39. Galloway J: Hodgkin's disease, Brit. M. J. 2: 1201, 1922. CrossrefMedlineGoogle Scholar40. Gilbert R: Radiotherapy in Hodgkin's disease (malignant granulomatosis). Anatomic and clinical foundations; governing principles; results, Am. J. Roentgenol. 41: 198, 1939. Google Scholar41. GordonGowLevittWeber MHAEWMFP: Recent advances in the pathology and treatment of lymphadenoma, Proc. Roy. Soc. Med. 27: 1035, 1934. MedlineGoogle Scholar42. Heussi M: Ueber Lymphogranulomatose besondere ihr familiäres Vorkommen, 1936, Fluntern, Zürich. Google Scholar43. JacksonParker HF: Hodgkin's disease and allied disorders, 1947, Oxford University Press, New York. Google Scholar44. Kaplan II: Hodgkin's disease in childhood, Arch. Pediat. 51: 325, 1934. Google Scholar45. Kasdon SC: Pregnancy and Hodgkin's disease with a report of three cases, Am. J. Obst. and Gynec. 57: 282, 1949. CrossrefMedlineGoogle Scholar46. Koranyi A, discussion to Borday: Einfahrungen in der pathologischen Anatomie und Histopathologie der Lymphogranulomatosis, Klin. Wchnschr. 1: 466, 1930, cited by Hoster, H. A., and Dratman, M. B.25 Google Scholar47. LaPorte D: Maladie de Hodgkin familiale, Presse méd. 44: 661, 1936. Google Scholar48. Leutkons K: Statistische und histologische Betrachtungen über die Hodgkinschen Granulomatose, Inaug. Diss., 1934, Freiberg, cited by Remde, W.21 Google Scholar49. McHeffeyPeterson GJRF: Hodgkin's disease occurring simultaneously in two brothers, J. A. M. A. 102: 521, 1934. CrossrefGoogle Scholar50. MazarStraus SAB: Marital Hodgkin's disease, Arch. Int. Med. 88: 819, 1951. CrossrefGoogle Scholar51. Morowitz P: Rassenhygiene und Bevölkerunspolitik. Erbliche und konstitutionelle Faktoren bei einigen Blutkrankheiten, München. med. Wchnschr. 83: 2073, 1936. Google Scholar52. Pflander U: Lymphogranulomatose Hodgkin et disposition hereditaire, Lausanne, 1948, cited by DeVore, J. W., and Doan, C. A.38 Google Scholar53. PrieselWinkelbauer AA: Placentarübertragung des Lymphgranuloms, Virchows Arch. f. path. Anat. 262: 749, 1926, cited by Kasdon, S. C.,45 and Cutler, M., and Buschke.62 CrossrefGoogle Scholar54. Sandick H: Hodgkin's disease involving the stomach, Gastroenterology 15: 135, 1950. CrossrefMedlineGoogle Scholar55. Schier WW: Familial Hodgkin's disease, Blood 9: 236, 1954. CrossrefMedlineGoogle Scholar56. Senator H, in Deutsche Klinik 3: 373, 1903, cited by Arkin, A.27 Google Scholar57. Smith CA: Hodgkin's disease in childhood. A clinical study with a resumé of the literature to-date, J. Pediat. 4: 12, 1934. CrossrefGoogle Scholar58. Videbaek A: Familial Hodgkin's disease, Acta haemat. 14: 200, 1955. CrossrefMedlineGoogle Scholar59. Uddstromer M: On the occurrence of lymphogranulomatosis in Sweden, 1915-1931, and some considerations as to its relation to tuberculosis, Acta tuberc. Scandinav. Supp. 1: 1-225, 1934. Google Scholar60. Warner EC: The treatment of lymphadenoma with a sensitized vaccine of the elementary body, Lancet 2: 417, 1936. CrossrefGoogle Scholar61. Weinstein A: Personal communication to DeVore, J. W., and Doan, C. A.38 Google Scholar62. CutlerBuschke MF, assisted by Cantril, S.: Cancer. Its diagnosis and treatment, 1939, W. B. Saunders Company, Philadelphia. Google Scholar63. HennessyRottino JPA: Hodgkin's disease in pregnancy with a report of twelve cases, Am. J. Obst. and Gynec. 63: 756, 1952. CrossrefMedlineGoogle Scholar64. SouthamDiamondCraver CMHDLF: Pregnancy during Hodgkin's disease, Cancer 9: 1141, 1956. CrossrefMedlineGoogle Scholar65. Homburger F: The biologic basis of cancer management, 1st Ed., 1957, Hoeber-Harper, New York. Google Scholar66. BurgerLehman REEP: Hodgkin's disease—a review of fifty-four cases, Arch. Surg. 43: 839, 1941. CrossrefGoogle Scholar67. Goldman LB: Hodgkin's disease. An analysis of 212 cases, J. A. M. A. 114: 1611, 1940. Google Scholar68. Bross ID: Personal communication. Google Scholar69. MacDonald EJ: The present incidence and survival picture in cancer and the promise of improved prognosis, Bull. Am. Coll. Surgeons 33: 75, 1948. MedlineGoogle Scholar70. McMahon B: Epidemiological evidence on the nature of Hodgkin's disease, Cancer 10: 1045, 1957. CrossrefMedlineGoogle Scholar71. Bersack S: Hodgkin's disease. Incidence and prognosis, Arch. Int. Med. 73: 233, 1944. CrossrefGoogle Scholar72. Cancer in Connecticut 1935-1951, Connecticut State Department of Health, 1955. Google Scholar73. DornCutler HFSJ: Morbidity from cancer in the U. S. A., Monograph 29, U. S. Department of Health, Education, and Welfare, Public Health Service, 1955, Washington, D. C. Google Scholar74. Hoster HA: A distribution study of Hodgkin's disease in the U. S. A., Ohio J. Sc. 44: 245, 1944. Google Scholar75. JacksonParker HF: Hodgkin's disease. General considerations, New England J. Med. 230: 1, 1944. CrossrefGoogle Scholar76. ShimkinOppermannBostickLow-Beer MBKCWLBV: Hodgkin's disease: an analysis of frequency, distribution, and mortality at the University of California Hospital, 1914-1951, Ann. Int. Med. 42: 136, 1955. LinkGoogle Scholar77. Shimkin MB: Hodgkin's disease mortality in the United States 1921-1951; race, sex and age distribution; comparison with leukemia, Blood 10: 1214, 1955. CrossrefMedlineGoogle Scholar78. Eisner KL: An unusual case of swelling of the liver and spleen with high continuous fever, New York M. J. 94: 584, 1911. Google Scholar79. Diamond HD: The results of therapy in Hodgkin's disease, Ann. New York Acad. Sc. 73: 357, 1958. CrossrefMedlineGoogle Scholar80. FinkbeinerCraverDiamond JALFHD: Prognostic signs in Hodgkin's disease, J. A. M. A. 156: 472, 1954. CrossrefMedlineGoogle Scholar81. Peters V: A study of survivals in Hodgkin's disease treated radiologically, Am. J. Roentgenol. 63: 299, 1950. Google Scholar82. Peters V: A study of Hodgkin's disease treated by irradiation, Am. J. Roentgenol. 79: 114, 1958. Google Scholar83. RosenbergDiamondCraver SAHDLF: Lymphosarcoma: a clinical review of 1269 cases, to be published. Google Scholar84. Murray GR: Hodgkin's disease, in Allbutt's System of medicine, Vol. 5, 1897, The Macmillan Company, New York, pp. 573-596, cited by Hoster et al.25 Google Scholar85. StreetAllen WWEG: Leukemia occurring in man and wife, New York State J. Med. 50: 1621, 1950. MedlineGoogle Scholar86. Gross L: Is cancer a communicable disease?, Cancer Research 4: 293, 1944. Google Scholar87. Hill AB: Principles of medical statistics, 6th Ed., 1955, Oxford University Press, New York. Google Scholar88. Beebe GW: Expected incidence of certain neoplastic diseases in veterans, National Research Council Memorandum, issued March, 1957. Google Scholar89. Anderson RC: Familial leukemia. A report of leukemia in five siblings, with a brief review of the genetic aspects of the disease, Am. J. Dis. Child. 81: 313, 1951. Google Scholar90. AndersonHezmann RCHW: Leukemia in twin children, J. A. M. A. 158: 652, 1955. CrossrefMedlineGoogle Scholar91. Ardashnikov SN: Lymphatic reactions among relatives of leukaemic patients, Brit. M. J. 2: 995, 1947. CrossrefGoogle Scholar92. DameshekSavittArbor WHAB: Chronic lymphatic leukemia in twin brothers aged fifty-six, J. A. M. A. 92: 1348, 1929. CrossrefGoogle Scholar93. Hornbaker JH: Chronic leukemia in three sisters, Am. J. M. Sc. 203: 322, 1942. CrossrefGoogle Scholar94. Meikle RW: Two varieties of leukemia in one family, Brit. M. J. 2: 468, 1944. CrossrefMedlineGoogle Scholar95. ReillyRapaportKarrMillsCarpenter EBSINWHGE: Familial chronic lymphatic leukemia, Arch. Int. Med. 90: 87, 1952. CrossrefGoogle Scholar96. Stewart FW: Occupational and post-traumatic cancer, Bull. New York Acad. Med. 23: 145, 1947. MedlineGoogle Scholar97. Razis DV: Unpublished data. Google Scholar98. Gross L: The vertical epidemic of mammary carcinoma in mice. The possible implications for the problem of cancer in general, Surg., Gynec. and Obst. 88: 295, 1949. MedlineGoogle Scholar99. LevitanRazisDiamondCraver RDVHDLF: ABO blood groups in Hodgkin's disease, Acta Hemat. 22: 12, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DENNIS V. RAZIS, M.D.; HENRY D. DIAMOND, M.D., F.A.C.P.; LLOYD F. CRAVER, M.D., F.A.C.P.Affiliations: New York, N. Y.*Received for publication April 6, 1959.From the Medical Neoplasia Service of the Department of Medicine, The Memorial Center for Cancer and Allied Diseases, New York, N. Y.; the Lymphoma Section, Division of Clinical Chemotherapy, the Sloan-Kettering Institute for Cancer Research, New York, N. Y.; and the Department of Medicine, Cornell University Medical College, New York, N. Y.†This study was financed by a grant from the Lloyd F. Craver Fund of the Memorial Center for Cancer and Allied Diseases, New York, N. Y.‡Special Fellow in Medical Neoplasia, The Memorial Center for Cancer and Allied Diseases, New York, N. Y.Requests for reprints should be addressed to Henry D. Diamond, M.D., Memorial Center for Cancer and Allied Diseases, 444 East Sixty-eighth Street, New York 21, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEpidemiology and Hereditary Aspects of Hodgkin and Non-Hodgkin LymphomasThe associations of HLA-A, -B, DRB1 alleles and haplotypes in Turkish lymphoma patientsHuman leukocyte antigens and genetic susceptibility to lymphomaEpidemiologyEpidemiology and Hereditary Aspects of Hodgkin and Non-Hodgkin LymphomasEpidemiologyFamilial Hodgkin's Lymphoma from the Perspective of HLAMalignant Lymphomas and LymphadenopathiesFamily matters in Hodgkin lymphomaReliability of Self-Reported Family History of Cancer in a Large Case–Control Study of LymphomaAnticipation in families with Hodgkin's and non-Hodgkin's lymphoma in their pedigreeFamily History of Hematopoietic Malignancy and Risk of LymphomaGermline mutations and polymorphisms in theNFKBIA gene in Hodgkin lymphomaGenetic susceptibility to Hodgkin's lymphoma associated with the human leukocyte antigen regionThe genetics of familial lymphomasChildhood Social Environment and Hodgkin's Lymphoma: New Findings from a Population-Based Case-Control StudyFamiliäre lymphatische und myeloische NeoplasienApparent Anticipation and Heterogeneous Transmission Patterns in Familial Hodgkin's and Non-Hodgkin's Lymphoma: Report from a Study Based on Swedish Cancer DatabaseThe incidence of lymphoma in first-degree relatives of patients with Hodgkin disease and non-Hodgkin lymphomaFamilial and metachronous malignant lymphoma: Absence of constitutional p53 mutationsPseudoautosomal Linkage of Hodgkin DiseaseAnticipation in Familial Hodgkin LymphomaFamilial Burkitt's lymphoma in NigeriansIntracranial Hodgkin's disease in two patients with familial Hodgkin's diseaseWhat Can we Learn About the Aetiology of Hodgkin’s Disease from Family Studies?Epstein-Barr virus in familial Hodgkin's diseaseGenetic Factors in Leukemia and LymphomaHodgkin's Disease in Children in the West Midlands, 1957–1986: A Large Population-Based StudyM. HodgkinAn unusual family cancer syndrome manifested in young siblingsImmune deficiency in family members of patients with Hodgkin's diseaseHodgkin's disease in two sistersFamilial Lymphomas A review of the literature with report of cases in JerusalemGenetic Diseases, Hamartomas, and Familial Occurrence of NeoplasmsImmune-deficiency in Hodgkin's disease (HD): a study of patients and healthy relatives in families with multiple casesFamilial Hodgkin's disease a clinical and laboratory investigationCase aggregation in young adult Hodgkin's disease. Etiologic evidence from a population experienceNon-Hodgkin malignant lymphomas and Hodgkin's disease in first-degree relativesQuantitative and functional abnormalities of total T lymphocytes in relatives of patients with Hodgkin's diseaseHodgkin's disease in married couplesHodgkin's Disease in SiblingsEpidemiologic comparison of cancer of the testis and Hodgkin's disease among young malesClustering of non-Hodgkin's lymphomasSynchronous Hodgkin's Disease in Monozygotic TwinsHLA IN FAMILIAL HODGKIN'S DISEASEHodgkin's disease susceptibility: Linkage to the HLA locus demonstrated by a new concordance methodMalignant Lymphoma in First-Degree Blood RelativesA procedure for investigating cancer cluster reportsHistiocytic lymphoma in chronic ulcerative colitisSimultaneous Hodgkin's disease in three siblings with identical HLA-genotypeHLA genotypes in familial Hodgkin's disease. Excess of HLA identical affected sibsIMMUNOBLASTIC LYMPHOMA IN HUSBAND AND WIFEThe Epidemiology Of LeukemiaHodgkin disease in monozygotic twins: A case reportMalignant lymphoma in four of five siblingsCurrent assessment of “case clustering” of lymphomas and leukemiasHodgkin disease: An analysis of 128 casesFamilial Hodgkin's Disease and the Major Histocompatibility ComplexImmunological depletion contributing to familial Hodgkin's diseaseClustering and aggregation of exposures in Hodgkin's diseaseHodgkin's Disease in SiblingsMalignant lymphoma of the small intestine in multiple family members.Association with an immunologic deficiencyFamily Distribution of Lymphocytotoxins in Hodgkin's DiseaseJ. RICHARD MENDIUS, B.S., RAPHAEL J. DeHORATIUS, M.D., RONALD P. MESSNER, M.D., RALPH C. WILLIAMS JR., M.D., F.A.C.P.Hodgkin's disease in the bone marrowHodgkin's disease in the bone marrowFamilial Leukaemia: A Study of 909 FamiliesFamily Studies in Cases with Malignant LymphomasEpidemiology of Hodgkin's Disease: Review and Etiologic LeadsFAMILIAL HODGKIN'S DISEASE: AN ENVIRONMENTAL AND GENETIC DISORDERAetiologic leads in the malignant lymphomasDie LymphogranulomatoseErbfaktoren bei häufigen KrankheitenHodgkin's disease in the first decadeTonsillectomy History in Hodgkin's DiseaseClustering in Hodgkin's DiseaseHodgkin's Disease: Cases with Features of a Community OutbreakN. J. VIANNA, M.D., M.S.P.H., P. GREENWALD, M.D., F.A.C.P., J. BRADY, A. K. POLAN, M.A., A. DWORK, B.S., J. MAURO, M.D., J. N. P. DAVIES, M.D., D.Sc, F.R.C.Path.Acute Leukemia with "Burkitt's Lymphoma Cells" and Burkitt's Lymphoma Simultaneous Onset in American Siblings; Description of a New EntityDAVID A. STEVENS, M.D., GREGORY T. O'CONOR, M.D., PAUL H. LEVINE, M.D., ROBERT B. ROSEN, M.D.Epidemiology of Hodgkin's diseaseEvidence for environmental factors in the etiology of Hodgkin's diseaseHodgkin's disease in three children from an Amish kindredDetection and Assessment of Case Clustering in Burkitt’s Lymphoma and Hodgkin’s DiseaseDetection and Assessment of Case Clustering in Burkitt’s Lymphoma and Hodgkin’s DiseaseDetection and Assessment of Case Clustering in Burkitt's Lymphoma and Hodgkin's DiseaseA study of space-time clustering in Hodgkin's disease in the Manchester region.EXTENDED EPIDEMIC OF HODGKIN'S DISEASE IN HIGH-SCHOOL STUDENTSNATURE OF HODGKIN'S DISEASE AGENTHodgkin's Disease in ChildrenHeredity, Emotions and Cancer ControlThe Association of Immune Disease and Malignant LymphomaDANIEL G. MILLER, M.D., F.A.C.P.Immunological deficiency and malignant lymphomaHeredity and Malignancies of The Reticuloendothelial System小児期惡性腫瘍の特殊性Hodgkin's DiseaseHodgkin's disease: Long survival in a study of 388 world war II army casesHodgkin's Disease — Prognosis, Treatment and Etiologic and Immunologic ConsiderationsHEREDITARY FACTORS IN HUMAN LEUKAEMIA: A REPORT OF FOUR CASES OF LEUKAEMIA IN A FAMILYLYMPHOSARCOMA: THE EFFECTS OF THERAPY AND SURVIVAL IN 1,269 PATIENTS IN A REVIEW OF 30 YEARS' EXPERIENCE*†SAUL A. ROSENBERG, M.D., HENRY D. DIAMOND, M.D., F.A.C.P., LLOYD F. CRAVER, M.D., F.A.C.P.Medical genetics 1959 1 November 1959Volume 51, Issue 5Page: 933-971KeywordsAutopsyBiopsyBrainCancer chemotherapyDizygotic twinsHodgkin lymphomaJewish peopleLymph nodesMonozygotic twinsSarcoma ePublished: 1 December 2008 Issue Published: 1 November 1959 PDF downloadLoading ...