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Genetic Aspects of Unconventional Virus Infections: The Basis of the Virino Hypothesis

2007; Wiley; Linguagem: Inglês

10.1002/9780470513613.ch5

ISSN

1935-4657

Autores

A.G. Dickinson, G. W. OUTRAM,

Tópico(s)

Animal Disease Management and Epidemiology

Resumo

Genetic Aspects of Unconventional Virus Infections: The Basis of the Virino Hypothesis A. G. Dickinson, A. G. Dickinson AFRC & MRC Neuropathogenesis Unit, Ogston Building, West Mains Road, Edinburgh EH9 3JF, UKSearch for more papers by this authorG. W. Outram, G. W. Outram AFRC & MRC Neuropathogenesis Unit, Ogston Building, West Mains Road, Edinburgh EH9 3JF, UKSearch for more papers by this author A. G. Dickinson, A. G. Dickinson AFRC & MRC Neuropathogenesis Unit, Ogston Building, West Mains Road, Edinburgh EH9 3JF, UKSearch for more papers by this authorG. W. Outram, G. W. Outram AFRC & MRC Neuropathogenesis Unit, Ogston Building, West Mains Road, Edinburgh EH9 3JF, UKSearch for more papers by this author Book Editor(s):Greg Bock, Greg Bock OrganizerSearch for more papers by this authorJoan Marsh, Joan MarshSearch for more papers by this author First published: 28 September 2007 https://doi.org/10.1002/9780470513613.ch5Citations: 27Book Series:Novartis Foundation Symposia AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onEmailFacebookTwitterLinkedInRedditWechat Summary The properties of genes involved directly or indirectly in the pathogenesis of scrapie and other unconventional (UCV) virus infections are reviewed. Reasons are presented for assigning paramount importance to the Sinc gene in mice and the Sip gene in sheep (the likely homologue of Sinc). The rationale is given for concluding that the agents of UCV infections have their own genomic molecules coding for strain differences. The virino hypothesis, which proposes that the infective form of the agent is an informational hybrid between the agent's genome and protective host proteins, is presented in detail, with an explanation of the postulated role of Sinc. References Bruce M, Dickinson AG 1979 Biological stability of different classes of scrapie agent. In: SB Prusiner, WJ Hadlow (eds) Slow transmissible diseases of the nervous system. Academic Press, New York, vol 2: p 71–86. Google Scholar Bruce M, Dickinson AG 1987 Biological evidence that scrapie agent has an independent genome. J Gen Virol 68: 79–89. 10.1099/0022-1317-68-1-79 PubMedWeb of Science®Google Scholar Carlson GA, Kingsbury DT, Goodmann PA et al 1986 Prion protein and scrapie incubation time genes are linked. Cell 46: 503–511. 10.1016/0092-8674(86)90875-5 CASPubMedWeb of Science®Google Scholar Carp RI, Callahan SM 1987 Scrapie incubation periods and end-point titers in mouse strains differing at the H-2D locus. Int Virol 26: 85–92. 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