Structure-Function Relationships Among RNA-Dependent RNA Polymerases
2007; Springer Science+Business Media; Linguagem: Inglês
10.1007/978-3-540-75157-1_7
ISSN2196-9965
AutoresKenneth Ng, Jamie J. Arnold, Craig E. Cameron,
Tópico(s)RNA and protein synthesis mechanisms
ResumoRNA-dependent RNA polymerases (RdRPs) play key roles in viral transcription and genome replication, as well as epigenetic and post-transcriptional control of cellular gene expression. In this article, we review the crystallographic, biochemical, and molecular genetic data available for viral RdRPs that have led to a detailed description of substrate and cofactor binding, fidelity of nucleotide selection and incorporation, and catalysis. It is likely that the cellular RdRPs will share some of the basic structural and mechanistic principles gleaned from studies of viral RdRPs. Therefore, studies of the viral RdRP establish a framework for the study of cellular RdRPs, an important yet understudied class of nucleic acid polymerases.
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