The Cellular Targets for the Action of Adjuvants: T-Adjuvants and B-Adjuvants
2008; Wiley; Linguagem: Inglês
10.1002/9780470720011.ch2
ISSN1935-4657
AutoresD. W. Dresser, Jennifer M. Phillips,
Tópico(s)Nuclear Receptors and Signaling
ResumoChapter 2 The Cellular Targets for the Action of Adjuvants: T-Adjuvants and B-Adjuvants D. W. Dresser, D. W. Dresser The National Institute for Medical Research, LondonSearch for more papers by this authorJennifer M. Phillips, Jennifer M. Phillips The National Institute for Medical Research, LondonSearch for more papers by this author D. W. Dresser, D. W. Dresser The National Institute for Medical Research, LondonSearch for more papers by this authorJennifer M. Phillips, Jennifer M. Phillips The National Institute for Medical Research, LondonSearch for more papers by this author Book Editor(s):G. E. W. Wolstenholme, G. E. W. WolstenholmeSearch for more papers by this authorJulie Knight, Julie KnightSearch for more papers by this author First published: 01 January 1973 https://doi.org/10.1002/9780470720011.ch2Citations: 9Book Series:Novartis Foundation Symposia AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onEmailFacebookTwitterLinkedInRedditWechat Summary This chapter contains section titled: Experiments Illustrating the Effect of Adjuvant on the Numbers of Cells Producing Antibody of Different Classes The Adjuvant Effect of Pertussis is Mediated Through T and B Cells Adjuvants with T- and B-orientation Timing of Administration of Adjuvant in Relation to the Injection of Antigen Conclusion Acknowledgments References Discussion References References Allison, A. C. & Da Vies, A. J. S., (1971) Requirement of thymus–dependent lymphocytes for potentiation by adjuvants of antibody formation. Nature (Lond.) 223, 330–332. 10.1038/233330a0 Web of Science®Google Scholar Anderson, H., (1972) Allotypic suppression of adult mouse spleen cells: cell differentiation, class restriction and allotypic exclusion. Eur. J. Immunol. 2, 11–17. 10.1002/eji.1830020104 CASPubMedWeb of Science®Google Scholar Andersson, J., Sjoberg, O. & Moller, G., (1972) Mitogens as probes for immunocyte activation and cellular cooperation. Transplant. Rev. 11, 131–177. 10.1111/j.1600-065X.1972.tb00048.x CASPubMedWeb of Science®Google Scholar Andersson, J., Moller, G. & Sjoberg, O., (1973) Selective induction of DNA synthesis in T and B lymphocytes. Eur. J. Immunol. 3, in press. CASPubMedWeb of Science®Google Scholar Bretscher, P., (1972) The control of humoral and associative antibody synthesis. Transplant. Rev. 11, 217–267. 10.1111/j.1600-065X.1972.tb00050.x CASPubMedWeb of Science®Google Scholar Chihara, G., Maeda, Y., Hamuro, J., Sasaka, T. & Fukuoka, F., (1969) Inhibition of mouse sarcoma 180 by polysaccharides from Lentinus edodes (Berk.) Sing. Nature (Lond.) 222, 687–688. 10.1038/222687a0 CASPubMedWeb of Science®Google Scholar Chihara, G., Hamuro, J., Maeda, Y., Arai, Y. & Fukuoka, F., (1970) Antitumour polysaccharide derived chemically from natural glucan (pachyman). Nature (Lond.) 225, 943–944. 10.1038/225943a0 CASPubMedWeb of Science®Google Scholar Chiller, J. M., Habicht, G. S. & Weigle, W. O., (1970) Cellular sites of immunologic unresponsiveness. Proc. Natl. Acad. Sci. U. S. A. 65, 551–556. 10.1073/pnas.65.3.551 CASPubMedWeb of Science®Google Scholar Claman, H. N., Chaperon, E. A. & Triplett, R. F., (1966) Thymus–marrow cell combination. Synergism in antibody production. Proc. Soc. Exp. Biol. Med. 122, 1167–1171. 10.3181/00379727-122-31353 CASPubMedWeb of Science®Google Scholar Davies, A. J. S., Leuchars, E., Wallis, V., Marchant, R. & Elliott, E. V., (1967) The failure of thymus–derived cells to produce antibody. Transplantation 5, 222–231. 10.1097/00007890-196703000-00010 Google Scholar Dresser, D. W., (1961) Effectiveness of lipid and lipidophilic substances as adjuvants. Nature (Lond.) 191, 1169–1171. 10.1038/1911169a0 CASPubMedWeb of Science®Google Scholar Dresser, D. W., (1962) The specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of a protein antigen. Immunology 5, 378–388. CASPubMedWeb of Science®Google Scholar Dresser, D. W., (1968a) Adjuvanticity of Vitamin A. Nature (Lond.) 217, 527–529. 10.1038/217527a0 CASPubMedWeb of Science®Google Scholar Dresser, D. W., (1968b) An assay for adjuvanticity. Clin. Exp. Immunol. 3, 877–888. CASPubMedGoogle Scholar Dresser, D. W., (1970) The immune response: circumvention and suppression. Proc. Fourth Int. Congr. Pharmacol. 4, 192–202. Google Scholar Dresser, D. W., (1972) The role of T cells and adjuvant in the immune response of mice to foreign erythrocytes. Eur. J. Immunol. 2, 50–57. 10.1002/eji.1830020111 CASPubMedWeb of Science®Google Scholar Dresser, D. W. & Greaves, M. F., (1973) Assays for antibody–producing cells. In Handbook of Experimental Immunology, 2nd edn ( D. M. Weir, ed.), chap. 27, Blackwell Scientific Publications, Oxford. Google Scholar Dresser, D. W. & Wortis, H. H., (1965) Use of an antiglobulin serum to detect cells producing antibody with low haemolytic efficiency. Nature (Lond.), 208, 859–861. 10.1038/208859a0 CASPubMedWeb of Science®Google Scholar Dresser, D. W., Wortis, H. H. & Anderson, H. R., (1970) The effect of pertussis vaccine on the immune response of mice to sheep red blood cells. Clin. Exp. Immunol. 7, 817–831. CASPubMedGoogle Scholar Finger, H., Beneke, G. & Emmerling, P., (1968) Einfluß von Bordetella pertussis auf das lymphatische Gewebe von Mausen. I. Erhohung der Milzgewichte Weiber Mause nach Injektion von Bordetella pertussis . Z. med. Mikrobiol. Immunol. 154, 23–34. 10.1007/BF02123075 CASPubMedGoogle Scholar Fischer, H., Rude, E. & Sellin, D., (1970) Membranaspekte der Immunologic. Naturwissenschaften 11, 507–513. 10.1007/BF00625316 Web of Science®Google Scholar Florey, H. W., (1969) Inflammation. In General Pathology, 4th edn ( H. W. Florey, ed.), pp. 40–123, Lloyd–Luke, London. Google Scholar Freund, J., (1951) The effect of paraffin oil and mycobacteria on antibody formation and sensitization. Am. J. Clin. Pathol. 21, 645–656. 10.1093/ajcp/21.7.645 CASPubMedWeb of Science®Google Scholar Freund, J., (1953) The response of immunized animals to specific and non–specific stimuli. In Nature and Significance of the Antibody Response ( A. M. Pappenheimer, ed.), pp. 46–68, Columbia University Press, New York. Google Scholar Glenny, A. T., Pope, C. G., Waddington, H. & Wallace, U., (1926) Immunological notes. XVII–XXIV. J. Pathol. 29, 31. 10.1002/path.1700290106 CASGoogle Scholar Golub, E. S. & Weigle, W. O., (1967) Studies on the induction of immunologic unresponsiveness. I. Effects of endotoxin and phytohemagglutinin. J. Immunol. 98, 1241–1247. CASPubMedWeb of Science®Google Scholar Greaves, M. F., (1971) The expression of immunoglobulin determinants on the surface of antigen–binding lymphoid cells in mice. I. An analysis of light and heavy chain restrictions on individual cells. Eur. J. Immunol. 1, 186–194. 10.1002/eji.1830010308 CASPubMedGoogle Scholar Herzenberg, L. A. & Warner, N., (1968) Genetic control of mouse immunoglobulins. In Regulation of the Antibody Response ( B. Cinader, ed.), p. 322, Thomas, Springfield, Ill. Google Scholar Jerne, N. K., Nordin, A. A. & Henry, C., (1963) The agar plaque technique for recognizing antibody–producing cells. In Cell Bound Antibodies ( B. Amos & H. Koprowski, eds.), pp. 109–125, Wistar Institute Press, Philadelphia. Google Scholar Johnson, A. G., Gaines, S. & Landy, M., (1956) Studies on the O antigen of Salmonella typhosa. V. Enhancement of antibody response to protein antigens by the purified lipopolysaccharide. J. Exp. Med. 103, 225–246. 10.1084/jem.103.2.225 CASPubMedWeb of Science®Google Scholar Katz, D. H., Paul, W. E., Goidl, E. A. & Benacerraf, B., (1971) Carrier function in antihapten antibody responses. III. Stimulation of antibody synthesis and facilitation of hapten–specific secondary antibody responses by graft–versus–host reactions. J. Exp. Med. 133, 169–186. 10.1084/jem.133.2.169 CASPubMedWeb of Science®Google Scholar Kincade, P. W., Lawton, A. R., Bockman, D. E. & Cooper, M. D., (1970) Suppression of immunoglobulin G synthesis as a result of antibody mediated suppression of immunoglobulin M synthesis in chickens. Proc. Natl. Acad. Sci. U. S. A. 67, 1918–1925. 10.1073/pnas.67.4.1918 CASPubMedWeb of Science®Google Scholar Kreth, H. W. & Williamson, A. R., (1971) Cell surveillance model for lymphocyte cooperation. Nature (Lond.) 234, 454–456. 10.1038/234454a0 CASPubMedWeb of Science®Google Scholar Lawton, A. R., Asofsky, R., Hylton, M. B. & Cooper, M. D., (1972) Suppression of immunoglobulin class synthesis in mice. I. Effects of treatment with antibody to μ–chain. J. Exp. Med. 135, 277–297. 10.1084/jem.135.2.277 PubMedWeb of Science®Google Scholar Maeda, Y. Y. & Chihara, G., (1971) Lentinan, a new immuno–accelerator of cell–mediated responses. Nature (Lond.) 229, 634. 10.1038/229634a0 CASPubMedWeb of Science®Google Scholar Maeda, Y. Y., Hamuro, J. & Chihara, G., (1971) The mechanisms of action of antitumour polysaccharides. I. The effects of antilymphocyte serum on the antitumour activity of lentinan. Int. J. Cancer 8, 41–46. 10.1002/ijc.2910080106 CASPubMedWeb of Science®Google Scholar Miller, J. F. A. P. & Mitchell, G. F., (1969) Thymus and antigen reactive cells. Transplant. Rev. 1, 3–42. 10.1111/j.1600-065X.1969.tb00135.x CASPubMedGoogle Scholar Mitchell, G. & Miller, J. F. A. P., (1968) Immunological activity of thymus and thoracic duct lymphocytes. Proc. Natl. Acad. Sci. (U. S. A.) 59, 296–303. 10.1073/pnas.59.1.296 CASPubMedGoogle Scholar Mitchison, N. A., (1967) Antigen recognition responsible for the induction in vitro of the immune response. Cold Spring Harbor Symp. Quant. Biol. 32, 431–439. 10.1101/SQB.1967.032.01.055 CASWeb of Science®Google Scholar Moller, G., Andersson, J. & Sjoberg, O., (1972) Lipopolysaccharides can convert heterologous red cells into thymus–independent antigens. Cell. Immunol. 4, 416–424. 10.1016/0008-8749(72)90043-3 CASPubMedWeb of Science®Google Scholar Munder, P. G., Ferber, E., Modolell, M. & Fischer, H., (1969) The influence of various adjuvants on the metabolism of phospholipids in macrophages. Int. Arch. Allergy Appl. Immunol. 36, 117–128. 10.1159/000230731 CASPubMedWeb of Science®Google Scholar Perkins, E. H., Sado, T. & Makinodan, T., (1969) Recruitment and proliferation of immunocompetent cells during the log phase of the primary antibody response. J. Immunol. 103, 668–678. CASPubMedWeb of Science®Google Scholar Rajewsky, K. & Rottländer, E., (1967) Tolerance specificity and the immune response to lactic dehydrogenase isoenzymes. Cold Spring Harbor Symp. Quant. Biol. 32, 547–554. 10.1101/SQB.1967.032.01.066 CASWeb of Science®Google Scholar Ramon, G., (1926) Ľanatoxine diphtérique et les anatoxines en général. Etude expérimental (Revue). J. Méd. Franç. 15, 381. Google Scholar Rowley, D. A., Fitch, F. W., Mosier, D. E., Solliday, S., Coppleston, L. W. & Brown, B. W., (1968) The rate of division of antibody–forming cells during the early primary immune response. J. Exp. Med. 127, 983–1002. 10.1084/jem.127.5.983 CASPubMedWeb of Science®Google Scholar Rupp, J. C, Moore, R. D. & Schoenberg, M. D., (1960) Stimulation of the reticuloendothelial system in the rabbit by Freund's adjuvant. Arch. Pathol. 70, 43–49. CASPubMedWeb of Science®Google Scholar Smith, R. O. & Wood, W. B., (1949) Cellular mechanisms of antibacterial defense in lymph nodes. II. The origin and filtration effect of granulocytes in the nodal sinuses during acute bacterial lymphadenitis. J. Exp. Med. 90, 567–576. 10.1084/jem.90.6.567 CASPubMedWeb of Science®Google Scholar Sterzl, J. & Riha, I., (1965) Detection of cells producing 7S antibodies by the plaque technique. Nature (Lond.) 208, 857. 10.1038/208858a0 Web of Science®Google Scholar Taub, R. N. & Gershon, R. K., (1972) The effect of localized injection of adjuvant material on the draining lymph node. III. Thymus dependence. J. Immunol. 108, 377–386. CASPubMedWeb of Science®Google Scholar Taub, R. N., Krantz, A. R. & Dresser, D. W., (1970) The effect of localized injection of adjuvant material on the draining lymph node. I. Histology. Immunology 18, 171–186. CASPubMedWeb of Science®Google Scholar Taylor, R. B., (1969) Cellular cooperation in the antibody response of mice to two serum albumins: specific function of thymus cells. Transplant. Rev. 1, 114–149. 10.1111/j.1600-065X.1969.tb00138.x PubMedGoogle Scholar Taylor, R. B. & Iverson, G. M., (1971) Hapten competition and the nature of cell–cooperation in the antibody response. Proc. R. Soc. Lond. B 176, 393–418. 10.1098/rspb.1971.0003 CASPubMedWeb of Science®Google Scholar Taylor, R. B. & Wortis, H. H., (1968) Thymus dependence of antibody response: variation with dose of antigen and class of antibody. Nature (Lond.) 220, 927–928. 10.1038/220927a0 PubMedWeb of Science®Google Scholar Taylor, R. B., Wortis, H. H. & Dresser, D. W., (1967) Production of class–specific immunoglobulin and antibody by thymectomized–irradiated mice bearing syngeneic and allogeneic thymus grafts. In Lymphocyte in Immunology and Haemopoiesis ( J. M. Yoffey, ed.), chap. 27, Arnold, London. Google Scholar Torrigiani, G., (1972) Quantitative estimation of antibodies in the immunoglobulin classes of the mouse. I. Effect of adjuvants on the antibody response to human serum albumin and keyhole limpet haemocyanin. Clin. Exp. Immunol. 11, 125–135. CASPubMedWeb of Science®Google Scholar Unanue, E. R., Askonas, B. A. & Allison, A. C., (1969) A role of macrophages in the stimulation of immune responses by adjuvants. J. Immunol. 103, 71–78. CASPubMedWeb of Science®Google Scholar Wortis, H. H., Dresser, D. W. & Anderson, H. R., (1969) Antibody production studied by means of the localized haemolysis in gel (LHG) assay. III. Mouse cells producing five different classes of antibody. Immunology 17, 93–110. CASPubMedWeb of Science®Google Scholar Allison, A. C., (1965) Arch. Gesamte Virusforsch, 2, 280. 10.1007/BF01267912 Web of Science®Google Scholar Anderson, H. R. & Dresser, D. W., (1972) The long–term distribution of antibody–forming cells. Eur. J. Immunol. 2, 410–413. 10.1002/eji.1830020505 CASPubMedWeb of Science®Google Scholar Andersson, B. & Blomgren, H., (1971) Evidence for thymus–independent humoral antibody production in mice against polyvinylpyrrolidone and E. coli lipopolysaccharide. Cell. Immunol. 2, 411–424. 10.1016/0008-8749(71)90052-9 CASPubMedWeb of Science®Google Scholar Andersson, J., Sjoberg, O. & Moller, G., (1972) Mitogens as probes for immunocyte activation and cellular cooperation. Transplant. Rev. 11, 131–177. 10.1111/j.1600-065X.1972.tb00048.x CASPubMedWeb of Science®Google Scholar Brody, N. E. & Siskind, G. W., (1969) Studies on antigenic competition. J. Exp. Med. 130, 821–832. 10.1084/jem.130.4.821 CASPubMedWeb of Science®Google Scholar Bretscher, P., (1972) The control of humoral and associative antibody synthesis. Transplant. Rev. 11, 217–267. 10.1111/j.1600-065X.1972.tb00050.x CASPubMedWeb of Science®Google Scholar Brooke, M. S., (1965) Conversion of immunological paralysis to immunity of endotoxin. Nature (Lond.) 206, 635–636. 10.1038/206635a0 CASPubMedWeb of Science®Google Scholar Byfield, P., Christie, G. H. & Howard, J. G., (1973) Alternative potentiating and inhibitory effects of a GVH reaction on antibody formation against a thymus–independent polysaccharide (SIII). J. Immunol. 111, 72. CASPubMedWeb of Science®Google Scholar Diamanstein, T. Wagner, B., Odenwald, M. V. & Schulz, G., (1971a) Stimulation of humoral antibody formation by polyanions. IV. The effect of dextran sulfate on the kinetics of secondary immune response in mice. Eur. J. Immunol. 1, 426–429. 10.1002/eji.1830010604 PubMedWeb of Science®Google Scholar Diamanstein, T., Meinhold, H. & Wagner, B., (1971b) Stimulation of humoral antibody formation by polyanions. V. Relationship between enhancement of sheep blood cell uptake by the spleen and adjuvant action of dextran sulfate. Eur. J. Immunol. 1, 429–432. 10.1002/eji.1830010605 PubMedWeb of Science®Google Scholar Dresser, D. W., Wortis, H. H. & Anderson, H. R., (1970) The effect of pertussis vaccine on the immune response of mice to sheep red blood cells. Clin. Exp. Immunol. 7, 817–837. CASPubMedGoogle Scholar Eidinger, D. & Baines, M. G., (1971) Further studies of competition of antigens. II. Cellular deficit or inhibitory factor: an indirect evaluation of the problem. Can. J. Microbiol. 17, 857–863. 10.1139/m71-138 CASPubMedWeb of Science®Google Scholar Feldmann, M., (1972) Cell interactions in the immune response in vitro. II. The requirement for macrophages in lymphoid cell collaboration. J. Exp. Med. 135, 1049–1058. 10.1084/jem.135.5.1049 CASPubMedWeb of Science®Google Scholar Feldmann, M. & Nossal, G. J. V., (1972) Tolerance, enhancement, and the regulation of interactions between T–cells, B–cells and macrophages. Transplant. Rev. 13, 3–34. 10.1111/j.1600-065X.1972.tb00058.x CASPubMedWeb of Science®Google Scholar Floersheim, G. L., (1966) Further studies pertaining to a B. pertussis factor inhibiting the tuberculin reaction. Experientia 22, 219–220. 10.1007/BF01900917 CASPubMedWeb of Science®Google Scholar Floersheim, G. L., (1969) Suppression of cellular immunity by Gram–negative bacteria. Antibiot. Chemother. 15, 407–417. 10.1159/000386793 CASPubMedWeb of Science®Google Scholar Hamaoka, T. & Katz, D. H., (1973) Cellular site of action of various adjuvants in antibody responses to hapten–carrier conjugates. J. Immunol, in press. Google Scholar Humphrey, J. H., (1962) Non–specific globulin response to Freund's adjuvant. In Colloque sur la Tolerance et la Tolerance naturelle (Royaumont, Paris), Centre National de la Recherche Scientifique, Paris. Google Scholar Katz, D. H., Paul, W. E. & Benacerraf, B., (1971) Carrier function in anti–hapten antibody responses. V. Analysis of cellular events in the enhancement of antibody responses by the ‘allogeneic effect’ in DNP–OVA–primed guinea pigs challenged with a heterologous DNP–conjugate. J. Immunol. 107, 1319. CASPubMedWeb of Science®Google Scholar Möller, G. & Sjoberg, O., (1970) Effect of antigenic competition on antigen–sensitive cells and on adoptively transferred immunocompetent celfs. Cell. Immunol. 1, 110. 10.1016/0008-8749(70)90064-X CASPubMedGoogle Scholar Ordal, J. C. & Grumet, F. C., (1972) Genetic control of the immune response to poly–L (Tyr, Glu)–poly–D, L–Ala–poly–L–Lys in nonresponder mice. J. Exp. Med. 136, 1195. 10.1084/jem.136.5.1195 CASPubMedWeb of Science®Google Scholar Osborne, D. P. JR & Katz, D. H., (1973) The allogeneic effect in inbred mice. III. Unique antigenic structural requirements in the expression of the phenomenon on unprimed cell populations in vivo . J. Exp. Med. 137, 991. 10.1084/jem.137.4.991 CASPubMedWeb of Science®Google Scholar Radovich, J. & Talmage, D. W., (1967) Antigenic competition: cellular or humoral. Science (Wash. D. C.) 158, 512–514. 10.1126/science.158.3800.512 PubMedWeb of Science®Google Scholar Taylor, R. B. & Iverson, G. M., (1971) Hapten competition and the nature of cell–cooperation in the antibody response. Proc. R. Soc. Lond. B 176, 393–418. 10.1098/rspb.1971.0003 CASPubMedWeb of Science®Google Scholar Veit, B. C. & Michael, J. G., (1972) The lack of thymic influence in regulating the immune response to Escherichia coli 0127 endotoxin. J. Immunol. 109, 547–553. CASPubMedWeb of Science®Google Scholar World Health Organization, (1973) W. H. O. Tech. Rep. Ser. no. 519. Google Scholar Zisman, B. & Allison, A. C., (1973) J. Gen. Virol. 19, 329–338. 10.1099/0022-1317-19-3-329 PubMedWeb of Science®Google Scholar Citing Literature Ciba Foundation Symposium 18 ‐ Immunopotentiation ReferencesRelatedInformation
Referência(s)