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Synthèse et configuration absolue des énantiomères du Vér apamil

1975; Wiley; Volume: 58; Issue: 7 Linguagem: Inglês

10.1002/hlca.19750580720

1522-2675

Henri Ramuz,

Synthesis and Catalytic Reactions

Synthesis and Absolute Confifguration of the Enantiomers of Verapamil . Starting from the acids IV‐(+) and IV‐(−), a synthesis of the enantiomers I‐(+) and I‐(−) of the coronary vasodilator Verapamil is described and their absolute configuration determined through a chemical filiation with the acid XII‐(S)‐(+).