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Acute Effect on the Aβ Isoform Pattern in CSF in Response to γ-Secretase Modulator and Inhibitor Treatment in Dogs

2010; IOS Press; Volume: 21; Issue: 3 Linguagem: Inglês

10.3233/jad-2010-100573

1875-8908

Erik Portelius, Bianca Van Broeck, Ulf Andréasson, Mikael K. Gustavsson, Marc Mercken, Henrik Zetterberg, Herman Borghys, Kaj Blennow,

Computational Drug Discovery Methods

Alzheimer's disease (AD) is associated with deposition of amyloid-β (Aβ) in the brain, which is reflected by low concentration of the Aβ1–42 peptide in the cerebrospinal fluid (CSF). The γ-secretase inhibitor LY450139 (semagacestat) lowers plasma Aβ1