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CYTOTOXIC ACTIVITIES OF PHLORETHOL AND FUCOPHLORETHOL DERIVATIVES ISOLATED FROM LAMINARIACEAE ECKLONIA CAVA

2011; Wiley; Volume: 35; Issue: 2 Linguagem: Inglês

10.1111/j.1745-4514.2010.00387.x

1745-4514

Yong Li, Zhong‐Ji Qian, Moon‐Moo Kim, Se‐Kwon Kim,

Marine and coastal plant biology

Journal of Food BiochemistryVolume 35, Issue 2 p. 357-369 CYTOTOXIC ACTIVITIES OF PHLORETHOL AND FUCOPHLORETHOL DERIVATIVES ISOLATED FROM LAMINARIACEAE ECKLONIA CAVA YONG LI, YONG LI Marine Bioprocess Research Center, Pukyong National University, Busan, Korea Pharmacy College, Chang-Chun University of Chinese Medicine, Changchun, 130117, ChinaSearch for more papers by this authorZHONG-JI QIAN, ZHONG-JI QIAN Marine Bioprocess Research Center, Pukyong National University, Busan, KoreaSearch for more papers by this authorMOON-MOO KIM, MOON-MOO KIM Department of Chemistry, Dong-Eui University, Busan, 614-714, KoreaSearch for more papers by this authorSE-KWON KIM, Corresponding Author SE-KWON KIM Marine Bioprocess Research Center, Pukyong National University, Busan, Korea Department of Chemistry, Pukyong National University, Busan, 608-737, Republic of Korea TEL: 82-51-629-7094; FAX: 82-51-629-7099; EMAIL: sknkim@pknu.ac.krSearch for more papers by this author YONG LI, YONG LI Marine Bioprocess Research Center, Pukyong National University, Busan, Korea Pharmacy College, Chang-Chun University of Chinese Medicine, Changchun, 130117, ChinaSearch for more papers by this authorZHONG-JI QIAN, ZHONG-JI QIAN Marine Bioprocess Research Center, Pukyong National University, Busan, KoreaSearch for more papers by this authorMOON-MOO KIM, MOON-MOO KIM Department of Chemistry, Dong-Eui University, Busan, 614-714, KoreaSearch for more papers by this authorSE-KWON KIM, Corresponding Author SE-KWON KIM Marine Bioprocess Research Center, Pukyong National University, Busan, Korea Department of Chemistry, Pukyong National University, Busan, 608-737, Republic of Korea TEL: 82-51-629-7094; FAX: 82-51-629-7099; EMAIL: sknkim@pknu.ac.krSearch for more papers by this author First published: 04 March 2011 https://doi.org/10.1111/j.1745-4514.2010.00387.xCitations: 29Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract ABSTRACT Ecklonia cava (EC) is a member of the family Laminariaceae, and it is an edible marine brown alga with various bioactivities. Five phlorotannin derivatives from the methanol extract of Ecklonia cava were isolated and described as fucodiphloroethol G (1) with phenylether bridges (phlorethol), and dieckol (2), 1-(3′,5′-dihydroxyphenoxy)-7-(2″,4″,6″-trihydroxyphenoxy)-2,4,9-trihydroxy-dibenzo-1,4-dioxin (3), eckol (4), and phlorofucofurofuroeckol A (5) with biaryl linkages (fucophlorethols), their structures were identified mainly by means of nuclear magnetic resonance spectral analysis. Compound 1 was obtained and characterized for the first time from this genus, and all proton resonances of 1 for phenolic hydroxyl groups were assigned completely as well, in addition, related bioactivity reports of 1 are not found anywhere so far. In this publication, cytotoxic action and future directions of these pholorotannins were evaluated first using four cultured human tumor cell lines (HeLa, HT1080, A549 and HT-29) and one cultured human normal cell line (MRC-5), with suggested explanation of the structure–activity relationship. PRACTICAL APPLICATIONS The main bioactive components in marine brown algae are polyphenol derivatives with unique chemical structures, namely phlorotannins. To date, a number of bioactivities have been explored using crude extracts containing phlorotannins and/or single phlorotannins from edible marine brown alga-Ecklonia cava such as anti-HIV, antioxidant, antiallergy, anti-plasmin, anti-inflammatory, antidiabetic, antiproliferative and anticancer activities. This report focuses on the cytotoxic activities of these pholorotannins, first using four cultured human tumor cell lines (HeLa, HT1080, A549 and HT-29) and one cultured human normal cell line (MRC-5), and with the suggested structure–activity relationship. The results indicate that these phlorotaninns possess cytotoxic activity at certain concentrations. Meanwhile, it provides experimental evidence for the further exploration of these compounds. Citing Literature Volume35, Issue2April 2011Pages 357-369 RelatedInformation