Portal de Periódicos da CAPES

Timolol/pilocarpine combination eye drops in open angle glaucoma and in ocular hypertension

1987; Wiley; Volume: 65; Issue: 5 Linguagem: Inglês

10.1111/j.1755-3768.1987.tb07048.x

1755-3768

Gunnar Høvding, Henry Aasved,

Retinal Diseases and Treatments

Abstract The effect of a newly developed ophthalmic solution containing both 0.5% timolol and 2% resp. 4% pilocarpine was compared with that of timolol 0.5% eye drops alone in 93 patients with manifest simple or capsular glaucoma or ocular hypertension. The medications were administered twice daily. The absolute additive effect of pilocarpine was small, although the combined solutions caused a statistically significantly greater reduction of the intraocular pressure than that achieved by timolol alone. This additional effect appeared to last at least 12 h. The effect of the test solutions containing 2% resp. 4% pilocarpine was very similar. Apart from the well‐known effects of the pilo‐carpine‐induced miosis, the combined test medications were generally well tolerated.