Portal de Periódicos da CAPES

Amino Acid Sequence Control of the Folding of the Parallel β-Helix, the Simplest β-Sheet Fold

2005; Springer Science+Business Media; Linguagem: Inglês

10.1007/11415770_35

1611-3349

Jonathan King, Cammie Haase-Pettingell, Ryan Simkovsky, Peter Weigele,

Ubiquitin and proteasome pathways

Deciphering how amino acid sequences direct polypeptide chains into their native folds remains a major unsolved problem. The most refractory aspect has been understanding the pathways and sequence control of β-sheet folding. This presumably reflects in part that residues that are far apart in the sequence will be intimately interacting in the folded β-structure.