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Adolescents At Risk for Alcohol Abuse Demonstrate Altered Frontal Lobe Activation During Stroop Performance

2010; Wiley; Volume: 35; Issue: 2 Linguagem: Inglês

10.1111/j.1530-0277.2010.01337.x

1530-0277

Marisa M. Silveri, Jadwiga Rogowska, Alexandra McCaffrey, Deborah Yurgelun‐Todd,

Neuroscience of respiration and sleep

Alcoholism: Clinical and Experimental ResearchVolume 35, Issue 2 p. 218-228 Adolescents At Risk for Alcohol Abuse Demonstrate Altered Frontal Lobe Activation During Stroop Performance Marisa M. Silveri, Marisa M. Silveri From the Brain Imaging Center (MMS, JR, AM), McLean Hospital, Belmont, Massachusetts; Department of Psychiatry (MMS, JR), Harvard Medical School, Boston, Massachusetts; and The Brain Institute (DAYT), University of Utah Medical School, and Mental Illness Research, Education and Clinical Center, VA Medical Center, Salt Lake City, Utah.Search for more papers by this authorJadwiga Rogowska, Jadwiga Rogowska From the Brain Imaging Center (MMS, JR, AM), McLean Hospital, Belmont, Massachusetts; Department of Psychiatry (MMS, JR), Harvard Medical School, Boston, Massachusetts; and The Brain Institute (DAYT), University of Utah Medical School, and Mental Illness Research, Education and Clinical Center, VA Medical Center, Salt Lake City, Utah.Search for more papers by this authorAlexandra McCaffrey, Alexandra McCaffrey From the Brain Imaging Center (MMS, JR, AM), McLean Hospital, Belmont, Massachusetts; Department of Psychiatry (MMS, JR), Harvard Medical School, Boston, Massachusetts; and The Brain Institute (DAYT), University of Utah Medical School, and Mental Illness Research, Education and Clinical Center, VA Medical Center, Salt Lake City, Utah.Search for more papers by this authorDeborah A. Yurgelun-Todd, Deborah A. Yurgelun-Todd From the Brain Imaging Center (MMS, JR, AM), McLean Hospital, Belmont, Massachusetts; Department of Psychiatry (MMS, JR), Harvard Medical School, Boston, Massachusetts; and The Brain Institute (DAYT), University of Utah Medical School, and Mental Illness Research, Education and Clinical Center, VA Medical Center, Salt Lake City, Utah.Search for more papers by this author Marisa M. Silveri, Marisa M. Silveri From the Brain Imaging Center (MMS, JR, AM), McLean Hospital, Belmont, Massachusetts; Department of Psychiatry (MMS, JR), Harvard Medical School, Boston, Massachusetts; and The Brain Institute (DAYT), University of Utah Medical School, and Mental Illness Research, Education and Clinical Center, VA Medical Center, Salt Lake City, Utah.Search for more papers by this authorJadwiga Rogowska, Jadwiga Rogowska From the Brain Imaging Center (MMS, JR, AM), McLean Hospital, Belmont, Massachusetts; Department of Psychiatry (MMS, JR), Harvard Medical School, Boston, Massachusetts; and The Brain Institute (DAYT), University of Utah Medical School, and Mental Illness Research, Education and Clinical Center, VA Medical Center, Salt Lake City, Utah.Search for more papers by this authorAlexandra McCaffrey, Alexandra McCaffrey From the Brain Imaging Center (MMS, JR, AM), McLean Hospital, Belmont, Massachusetts; Department of Psychiatry (MMS, JR), Harvard Medical School, Boston, Massachusetts; and The Brain Institute (DAYT), University of Utah Medical School, and Mental Illness Research, Education and Clinical Center, VA Medical Center, Salt Lake City, Utah.Search for more papers by this authorDeborah A. Yurgelun-Todd, Deborah A. Yurgelun-Todd From the Brain Imaging Center (MMS, JR, AM), McLean Hospital, Belmont, Massachusetts; Department of Psychiatry (MMS, JR), Harvard Medical School, Boston, Massachusetts; and The Brain Institute (DAYT), University of Utah Medical School, and Mental Illness Research, Education and Clinical Center, VA Medical Center, Salt Lake City, Utah.Search for more papers by this author First published: 12 November 2010 https://doi.org/10.1111/j.1530-0277.2010.01337.xCitations: 61 Reprint requests: Marisa M. Silveri, PhD, Brain Imaging Center, McLean Hospital, 115 Mill St., Belmont, MA 02478; Tel.: 617-855-2920; Fax: 617-855-2770; E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Background: Children and adolescents, family history positive (FH+) for alcoholism, exhibit differences in brain structure and functional activation when compared to family history negative (FH−) counterparts. Given that frontal brain regions, and associated reciprocal connections with limbic structures, undergo the most dramatic maturational changes during adolescence, the objective of this study was to compare functional brain activation during a frontally mediated test of response inhibition in 32 adolescents separated into low-risk (FH−) and high-risk (FH+) groups. Methods: Functional magnetic resonance (fMRI) blood oxygen level–dependent data were acquired at 1.5 Tesla during performance of Stroop Color Naming, Word Reading, and Interference. Preprocessing and statistical analyses, covaried for age, were conducted in SPM99 using a search territory that included superior, middle, and inferior frontal gyri (trigone region), anterior cingulate gyrus (CG), and left and right amygdala. Results: Significantly greater activation in the fronto-limbic search territory was observed in FH+ relative to FH− subjects during Stroop Interference. 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