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THE TREATMENT OF ARTHRITIC PAIN WITH DEMEROL, A NEW SYNTHETIC ANALGESIC

1945; American College of Physicians; Volume: 22; Issue: 3 Linguagem: Inglês

10.7326/0003-4819-22-3-382

1539-3704

Robert C. Batterman,

Drug-Induced Hepatotoxicity and Protection

Article1 March 1945THE TREATMENT OF ARTHRITIC PAIN WITH DEMEROL, A NEW SYNTHETIC ANALGESICROBERT C. BATTERMAN, M.D.ROBERT C. BATTERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-3-382 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWith the exception of salicylates for the polyarthritis of rheumatic fever and colchicine for gout, which are more or less specific for these conditions, the treatment of the chronic pain of arthritis has always been a difficult problem. It is admitted that the commonly used analgesics, such as salicylates and amidopyrine, have some value in the mild form of arthralgias or decrease to some extent the discomfort of chronic pain, but their potency is such that analgesia is never prolonged or complete. Too often the physician must resort to opiates, a practice which unfortunately is not very satisfactory. Of the...Bibliography1. EISLEBSCHAUMANN OO: Dolantin, ein neuartiges Spasmolytikum und Analgetikum (Chemisches und Pharmakologisches), Deutsch. med. Wchnschr., 1939, lxv, 967. CrossrefGoogle Scholar2. HIMMELSBACH CK: Studies of the addiction liability of Demerol (D-140), Jr. Pharm. and Exper. Therap., 1942, lxxv, 64-68. Google Scholar3. BATTERMANHIMMELSBACH RCCK: Demerol-a new synthetic analgesic, Jr. Am. Med. Assoc., 1943, cxxii, 222-226. CrossrefGoogle Scholar4. HIMMELSBACH CK: Further studies of the addiction liability of Demerol, Jr. Pharm. and Exper. Therap., 1943, lxxix, 5-9. Google Scholar5. BATTERMAN RC: Clinical effectiveness and safety of a new synthetic analgesic drug, Demerol, Arch. Int. Med., lxxi, 345-356. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT C. BATTERMAN, M.D.Affiliations: New York, N. Y.*Received for publication March 16, 1944.From the Department of Therapeutics, New York University College of Medicine and the Third (New York University) Medical Division of Bellevue Hospital.†Demerol is 1-methyl 4-phenyl-piperidine 4-carboxylic acid ethyl ester hydrochloride. It was introduced in Europe as "eudolat," and it was subsequently known on that continent and in South America as "dolantin." The Winthrop Chemical Company, Inc., graciously supplied us with the drug and with other aid in connection with this investigation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDemerol premedication in the ambulatory patient 1 March 1945Volume 22, Issue 3Page: 382-385KeywordsAnalgesicsArthralgiaDrugsGoutHospital medicineOpiatesPainRheumatic feverRheumatic painSalicylates ePublished: 1 December 2008 Issue Published: 1 March 1945 PDF downloadLoading ...