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Plasma Amyloid-β as a Function of Age, Level of Intellectual Disability, and Presence of Dementia in Down Syndrome

2011; IOS Press; Volume: 23; Issue: 3 Linguagem: Inglês

10.3233/jad-2010-101335

1875-8908

Elizabeth Head, Eric Doran, Mihaela Nistor, MARYANN HILL, Frederick A. Schmitt, Richard J. Haier, Ira T. Lott,

Dementia and Cognitive Impairment Research

Adults with Down syndrome (DS) are at risk for developing Alzheimer's disease (AD). While plasma amyloid-β (Aβ) is known to be elevated in DS, its relationship to cognitive functioning is unknown. To assess this relationship, samples from two groups