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Scientific Opinion on BSE/TSE infectivity in small ruminant tissues

2010; Wiley; Volume: 8; Issue: 12 Linguagem: Inglês

10.2903/j.efsa.2010.1875

1831-4732

Prion Diseases and Protein Misfolding

EFSA JournalVolume 8, Issue 12 1875 OpinionOpen Access Scientific Opinion on BSE/TSE infectivity in small ruminant tissues EFSA Panel on Biological Hazards (BIOHAZ), EFSA Panel on Biological Hazards (BIOHAZ)Search for more papers by this author EFSA Panel on Biological Hazards (BIOHAZ), EFSA Panel on Biological Hazards (BIOHAZ)Search for more papers by this author First published: 02 December 2010 https://doi.org/10.2903/j.efsa.2010.1875Citations: 5 Panel members: Olivier Andreoletti, Herbert Budka, Sava Buncic, John D Collins, John Griffin, Tine Hald, Arie Havelaar, James Hope, Günter Klein, James McLauchlin, Christine Müller-Graf, Christophe Nguyen-The, Birgit Noerrung, Luisa Peixe, Miguel Prieto Maradona, Antonia Ricci, John Sofos, John Threlfall, Ivar Vågsholm, Emmanuel Vanopdenbosch. Correspondence: biohaz@efsa.europa.eu Acknowledgement: The Panel wishes to thank the members of the Working Group on BSE/TSE infectivity in small ruminant tissues: Olivier Andreoletti, Sylvie Benestad, Bossers Alex, Christian Ducrot, Alexandre Fediaevsky, Christine Hoffmann, James Hope, Ciriaco Ligios and Marion Simmons for the preparatory work on this scientific opinion. Adoption date: 21 October 2010 Published date: 2 December 2010 Question number: EFSA-Q-2010-00052 On request from: European Commission AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract The objectives addressed were i) to provide an update on TSE (Transmissible Spongiform Encephalopathy) infectivity distribution in small ruminant tissues; and ii) to indicate based on the current epidemiological situation as regards to BSE (Bovine Spongiform Encephalopathy) in the small ruminant population in the EU (European Union), whether a review of the existing SRM (Specified Risk Materials) list for small ruminants should be envisaged with regard to the potential exposure to the BSE agent. The appraisal was addressed by reviewing for Classical scrapie, BSE and Atypical scrapie in small ruminants aspects related to: i) tissue infectivity distribution according to the age and the genotype of sheep and goats; and ii) the infectious load in the different tissues. In order to perform the assessment all the currently available scientific results were reviewed, and data on TSE monitoring in small ruminants in the EU and on small ruminants slaughtered by species and age category in each EU Member State were considered. The reduction of the infectivity associated to the carcass of an infected individual achieved by the current SRM policy in small ruminants for Classical scrapie and BSE was estimated. The total number of Classical scrapie infected sheep and goats that could enter yearly into the food chain was provided. Moreover, considerations about Atypical scrapie were given. A set of simulations allowing estimating the impact of different policy options on the BSE infectious load potentially present in an infected sheep was provided. Citing Literature Volume8, Issue12December 20101875 ReferencesRelatedInformation