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Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects

2008; Wiley; Volume: 154; Issue: 8 Linguagem: Inglês

10.1038/bjp.2008.210

1476-5381

Mohi Iqbal Mohammed Abdul, Xiaorui Jiang, Kenneth M. Williams, Richard O. Day, Basil D. Roufogalis, Winston Liauw, Hongmei Xu, Andrew J. McLachlan,

Hormonal Regulation and Hypertension

Patients commonly take complementary medicines in conjunction with warfarin yet evidence supporting the safety or the risk of a herb-drug interaction is lacking. The aim of this study was to investigate the possible impact of two commonly used herbal medicines, garlic and cranberry, on the pharmacokinetics and pharmacodynamics of warfarin in healthy male subjects.