Unifying Nomenclature for the Isoforms of the Lysosomal Membrane Protein LAMP‐2
2005; Wiley; Volume: 6; Issue: 11 Linguagem: Inglês
10.1111/j.1600-0854.2005.00337.x
ISSN1600-0854
AutoresEeva‐Liisa Eskelinen, Ana María Cuervo, Matthew R.G. Taylor, Ichizo Nishino, Janice S. Blum, J. Fred Dice, Ignacio V. Sandoval, Jennifer Lippincott‐Schwartz, J. Thomas August, Paul Säftig,
Tópico(s)Cellular transport and secretion
ResumoThe present nomenclature of the splice variants of the lysosome-associated membrane protein type 2 (LAMP-2) is confusing. The LAMP-2a isoform is uniformly named in human, chicken, and mouse, but the LAMP-2b and LAMP-2c isoforms are switched in human as compared with mouse and chicken. We propose to change the nomenclature of the chicken and mouse b and c isoforms to agree with that currently used for the human isoforms. To avoid confusion in the literature, we further propose to adopt the use of capital letters for the updated nomenclature of all the isoforms in all three species: LAMP-2A, LAMP-2B, and LAMP-2C.
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