Portal de Periódicos da CAPES

The Role of CD28 and CTLA4 in the Function and Homeostasis of CD4 + CD25 + Regulatory T Cells

2003; Wiley; Linguagem: Inglês

10.1002/0470871628.ch5

1935-4657

Elisa K. Boden, Qizhi Tang, H Bour, Jeffrey A. Bluestone,

Atherosclerosis and Cardiovascular Diseases

The Role of CD28 and CTLA4 in the Function and Homeostasis of CD4+CD25+ Regulatory T Cells Elisa Boden, Elisa Boden UCSF Diabetes Center, University of California, San Francisco, 513 Parnassus Avenue, Box 0540, HSW Room 1114, San Francisco, CA 94143-0540, USASearch for more papers by this authorQizhi Tang, Qizhi Tang UCSF Diabetes Center, University of California, San Francisco, 513 Parnassus Avenue, Box 0540, HSW Room 1114, San Francisco, CA 94143-0540, USASearch for more papers by this authorHelene Bour-Jordan, Helene Bour-Jordan UCSF Diabetes Center, University of California, San Francisco, 513 Parnassus Avenue, Box 0540, HSW Room 1114, San Francisco, CA 94143-0540, USASearch for more papers by this authorJeffrey A. Bluestone, Corresponding Author Jeffrey A. Bluestone UCSF Diabetes Center, University of California, San Francisco, 513 Parnassus Avenue, Box 0540, HSW Room 1114, San Francisco, CA 94143-0540, USAUCSF Diabetes Center, University of California, San Francisco, 513 Parnassus Avenue, Box 0540, HSW Room 1114, San Francisco, CA 94143-0540, USASearch for more papers by this author Elisa Boden, Elisa Boden UCSF Diabetes Center, University of California, San Francisco, 513 Parnassus Avenue, Box 0540, HSW Room 1114, San Francisco, CA 94143-0540, USASearch for more papers by this authorQizhi Tang, Qizhi Tang UCSF Diabetes Center, University of California, San Francisco, 513 Parnassus Avenue, Box 0540, HSW Room 1114, San Francisco, CA 94143-0540, USASearch for more papers by this authorHelene Bour-Jordan, Helene Bour-Jordan UCSF Diabetes Center, University of California, San Francisco, 513 Parnassus Avenue, Box 0540, HSW Room 1114, San Francisco, CA 94143-0540, USASearch for more papers by this authorJeffrey A. Bluestone, Corresponding Author Jeffrey A. Bluestone UCSF Diabetes Center, University of California, San Francisco, 513 Parnassus Avenue, Box 0540, HSW Room 1114, San Francisco, CA 94143-0540, USAUCSF Diabetes Center, University of California, San Francisco, 513 Parnassus Avenue, Box 0540, HSW Room 1114, San Francisco, CA 94143-0540, USASearch for more papers by this author Book Editor(s):Gregory Bock, Gregory Bock OrganizerSearch for more papers by this authorJamie Goode, Jamie GoodeSearch for more papers by this author First published: 10 September 2003 https://doi.org/10.1002/0470871628.ch5Citations: 32Book Series:Novartis Foundation Symposia Series Editor(s): Novartis Foundation, Novartis FoundationSearch for more papers by this author AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onFacebookTwitterLinked InRedditWechat Summary CD4+CD25+ T cells regulate a variety of autoimmune and alloimmune responses including the development of autoimmune diabetes in non-obese diabetic (NOD) mice. We have examined the role of CD28/CTLA4/B7 interactions in the expansion and survival of CD4+CD25+ regulatory T cells (Treg) in this setting. CD28/B7 interactions are essential in the development of Treg in the thymus and for their survival in the periphery. The CD28-mediated homeostasis of these cells is independent of IL2, OX40, CD40L, and survival factor Bcl-XL. In addition, analysis of Treg from CTLA4-deficient mice suggests that CTLA4 expression is not required for their development or function. However, non-activating anti-CTLA4 antibodies blocked the suppressor activity of regulatory cells in vitro. Thus, clinical application of co-stimulatory blockade using agents such as CTLA4Ig in the treatment of autoimmune disease may result in complicated outcomes. Citing Literature Generation and Effector Functions of Regulatory Lymphocytes: Novartis Foundation Symposium 252, Volume 252 RelatedInformation