Produção Nacional
Estudo de padronização da pele de cobra espécie - Boa constrictor - como modelo de estrato córneo para permeação de fármacos
2005; Associação Sergipana de Ciências; Volume: 1; Issue: 7 Linguagem: Inglês
ISSN
1808-2793
AutoresRogéria de Souza Nunes, Jacqueline Resende de Azevedo, Ana Paula Lemos Vasconcelos, Newton Lindolfo Pereira,
Tópico(s)Advanced Drug Delivery Systems
ResumoThe potential usefulness of snake skin Boa constrictor as a model membrane for percutaneous drug release was examined. There are similarities between shed snake skin and human stratun corneum en terms of structure, composition, lipid content, water permeability, etc. Considering the similariries snake skin and human skin the Boa constrictor was used as a barrier for an in vitro permeation, the indomethacin was selected as a model of drug, indicated narrower variation of results in coefficients of variation and reproductibility of permeation profiles.
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