The Role of Activation‐Induced Deaminase in Antibody Diversification and Chromosome Translocations
2007; Elsevier BV; Linguagem: Inglês
10.1016/s0065-2776(06)94003-6
ISSN1557-8445
AutoresAlmudena R. Ramiro, Bernardo Reina‐San‐Martin, Kevin M. McBride, Mila Janković, Vasco M. Barreto, André Nussenzweig, Michel C. Nussenzweig,
Tópico(s)DNA Repair Mechanisms
ResumoAlthough B and T lymphocytes are similar in many respects including diversification of their antigen receptor genes by V(D)J recombination, 95% of all lymphomas diagnosed in the western world are of B‐cell origin. Many of these are derived from mature B cells [Kuppers, R. (2005). Mechanisms of B‐cell lymphoma pathogenesis. Nat. Rev. Cancer 5, 251–262] and display hallmark chromosome translocations involving immunoglobulin genes and a proto‐oncogene partner whose expression becomes deregulated as a result of the translocation reaction [Kuppers, R. (2005). Mechanisms of B‐cell lymphoma pathogenesis. Nat. Rev. Cancer 5, 251–262; Kuppers, R., and Dalla‐Favera, R. (2001). Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 20, 5580–5594]. These translocations are essential to the etiology of B‐cell neoplasms. Here we will review how the B‐cell specific molecular events required for immunoglobulin class switch recombination are initiated and how they contribute to chromosome translocations in vivo.
Referência(s)