Portal de Periódicos da CAPES

CLINICAL STUDIES ON BILATERAL COMPLETE ADRENALECTOMY IN PATIENTS WITH SEVERE HYPERTENSIVE VASCULAR DISEASE

1952; American College of Physicians; Volume: 37; Issue: 5 Linguagem: Inglês

10.7326/0003-4819-37-5-972

1539-3704

George W. Thorn, J. Hartwell Harrison, John P. Merrill, Modestino G. Criscitiello, Thomas F. Frawley, John T. Finkenstaedt,

Adrenal Hormones and Disorders

Article1 November 1952CLINICAL STUDIES ON BILATERAL COMPLETE ADRENALECTOMY IN PATIENTS WITH SEVERE HYPERTENSIVE VASCULAR DISEASEGEORGE W. THORN, F.A.C.P., J. HARTWELL HARRISON, JOHN P. MERRILL, MODESTINO G. CRISCITIELLO, THOMAS F. FRAWLEY, JOHN T. FINKENSTAEDTGEORGE W. THORN, F.A.C.P.Search for more papers by this author, J. HARTWELL HARRISONSearch for more papers by this author, JOHN P. MERRILLSearch for more papers by this author, MODESTINO G. CRISCITIELLOSearch for more papers by this author, THOMAS F. FRAWLEYSearch for more papers by this author, JOHN T. FINKENSTAEDTSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-5-972 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe aggravation of hypertensive cardiovascular disease which follows ACTH administration1, 2 lends support to the concept that amelioration of the vascular disease might follow a critical reduction in the function of the adrenal cortex. Further evidence in support of the thesis that the adrenal cortical secretions are involved in the maintenance of hypertension has been presented in another publication by one of us.3The importance of the salt-retaining adrenal hormones in maintaining hypertension is suggested by the authors' experience in the treatment of hypertensive patients who subsequently have developed Addison's disease (figures 1 and 2). Under these circumstances a...Bibliography1. ThornForshamFrawleyHillRocheStaehelinWilson GWPHTFSRMDDL: Medical progress: the clinical usefulness of ACTH and cortisone, New England J. Med. 242: 783, 824, 865, 1950. CrossrefMedlineGoogle Scholar2. Frawley TF: The recognition and prevention of the complications of ACTH and cortisone therapy, Arch. Indust. Hygiene and Occupational Med. 3: 587-598 (June) 1951. Google Scholar3. Merrill JP: The role of the adrenal in hypertension, Ann. Int. Med. 37: 966, 1952. LinkGoogle Scholar4. ThornForshamFrawleyWilsonRenoldFredricksonJenkins GWPHTFDLAEDSD: Advances in the diagnosis and treatment of adrenal insufficiency, Am. J. Med. 10: 595, 1951. CrossrefMedlineGoogle Scholar5. GreenNelsonDoddsSmalley DMJNGARE: Bilateral adrenalectomy in malignant hypertension and diabetes, J. A. M. A. 144: 439, 1950. CrossrefMedlineGoogle Scholar6. LukensWolferth FDCC: Observations on subtotal adrenalectomy in hypertension. Presented before the Am. Clin. and Climatological Assoc., Stockbridge, Mass., October 16, 17, 18, 1950. Google Scholar7. WolferthJeffersLukensZintelHafkenschiel CCWAFDHAJH: Observations on the results of subtotal adrenalectomy in the treatment of severe, otherwise intractable hypertension and their bearing on the mechanism by which hypertension is maintained, Ann. Int. Med. 35: 8, 1951. LinkGoogle Scholar8. Shorr E: Participation of hepatorenal vasotropic factors in experimental renal hypertension, Am. J. Med. 4: 120, 1948. CrossrefMedlineGoogle Scholar9. Schroeder HA: Pathogenesis of hypertension, Am. J. Med. 10: 189, 1951. CrossrefMedlineGoogle Scholar10. GoldenbergAranow MH: Diagnosis of pheochromocytoma by the adrenergic blocking action of benzodioxan, J. A. M. A. 143: 1139, 1950. CrossrefMedlineGoogle Scholar11. GibsonPeacockSeligmanSack JGWCAMT: Circulating red cell volume measured simultaneously by the radioactive iron and dye methods, J. Clin. Investigation 25: 838, 1946. CrossrefGoogle Scholar12. Addis T: Glomerular nephritis; diagnosis and treatment, 1949, The Macmillan Co., New York. Google Scholar13. Archibald RM: Colorimetric determination of urea, J. Biol. Chem. 157: 507, 1945. CrossrefGoogle Scholar14. Schreiner GE: Determination of inulin by means of resorcinol, Proc. Soc. Exper. Biol. and Med. 74: 117, 1950. CrossrefMedlineGoogle Scholar15. RoeEpsteinGoldstein JHTHNP: A photometric method for the determination of inulin in plasma and urine, J. Biol. Chem. 178: 839, 1949. CrossrefMedlineGoogle Scholar16. NewmanGilmanPhilips EVAFS: The renal clearance of thiosulfate in man, Bull. Johns Hopkins Hosp. 79: 229, 1946. MedlineGoogle Scholar17. FinkelsteinAliminosaSmith NLMHW: The renal clearances of hippuric acid and pyridone derivatives, Am. J. Physiol. 133: 276, 1941. Google Scholar18. ThornForshamPruntyHills GWPHFTAG: The response to pituitary adrenocorticotrophic hormone as a test of adrenal cortical insufficiency, J. A. M. A. 137: 1005, 1948. CrossrefMedlineGoogle Scholar19. CallowCallowEmmons NHRKCW: Colorimetric determination of substances containing the grouping CH2-CO in urine extracts and an indication of androgen content, Biochem. J. 32: 1312, 1938. CrossrefMedlineGoogle Scholar20. DaughadayJaffeWilliams WHHRH: Chemical assay for "cortin" determination of formaldehyde liberated on oxidation with periodic acid, J. Clin. Endocrinol. 8: 166, 1948. CrossrefGoogle Scholar21. RenoldForshamMaisterenaThorn AEPHJGW: Intravenous ACTH: a preliminary report, New England J. Med. 244: 796, 1951. CrossrefMedlineGoogle Scholar22. FrawleyThorn TFGW: The relation of the salivary Na:K ratio to adrenal cortical activity, Proc. 2nd Clinical ACTH Conf. (Ed. John R. Mote), Vol. I, 1951, Blakiston, Philadelphia, p. 115. Google Scholar23. SchalesSchales OSS: A simple and accurate method for determination of chloride in biological fluids, J. Biol. Chem. 140: 879, 1941. CrossrefGoogle Scholar24. AsperSchalesSchales SPOSS: Importance of controlling pH in the Schales and Schales method of chloride determination, J. Biol. Chem. 168: 779, 1947. CrossrefMedlineGoogle Scholar25. Hardy AC: A new recording spectrophotometer, J. Optic. Soc. Am. 25: 305, 1935. CrossrefGoogle Scholar26. ThornJenkinsMcCrackenGarcia-ReyesReddy GWDBHJAWJ: Recent studies on ACTH and cortisone (Abstract), Tr. A. Am. Physicians, 1952. In press. MedlineGoogle Scholar27. Girgolaff SS: Zur Technik der Nebennierene Exstirpation, Zentralbl. Chir. 49: 1361, 1922. Google Scholar28. Crile G: Indications for and end-results in 308 denervations of adrenal glands, Am. J. Surg. 24: 378, 1934. CrossrefGoogle Scholar29. DeCourcy JH: The technique of adrenalectomy and adrenal denervation, Am. J. Surg. 30: 404, 1935. CrossrefGoogle Scholar30. Young HH: Genital abnormalities: hermaphroditism and related adrenal diseases, chapter on the adrenogenital syndrome, 1937, Williams and Wilkins Co., Baltimore, pp. 227-268. Google Scholar31. CahillMelicow GFMM: Tumors of the adrenal gland, J. Urol. 64: 1, 1950. CrossrefMedlineGoogle Scholar32. HugginsScott CWW: Bilateral adrenalectomy: clinical features and urinary excretion of 17-ketosteroids and estrogens, Ann. Surg. 122: 1031, 1945. CrossrefGoogle Scholar33. ThornRenoldWilsonFrawleyJenkinsGarcia-ReyesForsham GWAEDLTFDJAPH: Clinical studies on the activity of orally administered cortisone, New England J. Med. 245: 549, 1951. CrossrefMedlineGoogle Scholar34. HallMcCrackenThorn TCBHGW: Skin pigmentation in relation to adrenal cortical function, J. Clin. Endocrinol. 1952. In press. Google Scholar35. HugginsBergenstal CDM: Inhibition of human mammary and prostatic cancers by adrenalectomy, Cancer Research 12: 134, 1952. MedlineGoogle Scholar36. Frawley TF: Personal communication. Google Scholar37. HaynesForshamThornDexter FWPHGWL: Effect of pituitary adrenocorticotropin on the plasma hypertensinogen concentration of dogs, Federation Proc. 8: 70, 1949. Google Scholar38. HarrisonThornCriscitiello JHGWMG: A study of bilateral total adrenalectomy in malignant hypertension and chronic nephritis, J. Urol. 67: 405, 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication August 8, 1952.From the Medical and Surgical Clinics, Peter Bent Brigham Hospital, and the Departments of Medicine and Surgery, Harvard Medical School, Boston, Massachusetts.A preliminary report of this study was presented before the Association of American Physicians in Atlantic City, May 1, 1951, and was abstracted in Tr. A. Am. Physicians 64: 126, 1951. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA Study of Adrenal Insufficiency After Treatment of Hypertension by Bilateral Sympathectomy Plus Unilateral AdrenalectomyStudies on the Sodium-Retaining Effect of Adrenal Cortical SteroidsThe introduction of ganglion blocking drugs for the treatment of hypertension.Nephrotic Syndrome: Vasoconstriction and Hypervolemic Types Indicated by Renin-Sodium ProfilingJAY I. MELTZER, M.D., HANS J. KEIM, M.D., JOHN H. LARAGH, M.D., JEAN E. SEALEY, D.Sc, KUNG-MING JAN, M.D., SHU CHIEN, M.D.The Surgical Treatment of HypertensionNeoplasms of the Adrenal GlandCardiovascular SystemPLASMA-RENIN AND ALDOSTERONE SECRETION IN HYPERTENSIVE PATIENTS WITH RENAL OR RENAL ARTERY LESIONSPhysiology of the kidneyA Review of the Role of Bilateral Adrenalectomy in HypertensionAldosteronismEndocrine Factors in Congestive Heart Failure: Vasopressin, Aldosterone and AngiotensinDer sekundäre Aldosteronismus Herz-, Leber- und NierenkrankerHyperplasia of the Adrenal Medulla in Hypertension of ChildrenRenal circulation in congestive heart failureRenal function and renal impairment in congestive heart failureSurgery of the adrenalsSpätresultate der chirurgischen Therapie (Sympathektomie und Adrenalektomie)Behandlung der benignen und malignen HypertonieHypertonieHypertonieThe relationship of the adrenal cortex to hypertension∗Transmembrane gationic gradient and blood pressure regulationCAUSATIVE RELATIONSHIPS OF PARATHYROID HORMONE TO RENOGENIC AND RENIPRIVAL CARDIOVACULAR DISEASESelective hypoaldosteronismACTH, Trijodthyronin und CortisoneBilateral adrenalectomy for hypertensive vascular diseaseRenin und Hypertensin, physiologische oder pathologische Wirkstoffe?The pathogenesis of essential hypertensionMALIGNANT HYPERTENSION WITH INCREASED SECRETION OF ALDOSTERONE AND DEPLETION OF POTASSIUMNebennierenrinde und Wasser-Salzstoffwechsel unter besonderer Ber�cksichtigung von AldosteronObservations of human adrenal cortical deficiencyAcute Adrenal Insufficiency and Acute Myocardial InfarctionEvidence of Decreased Vascular Permeability in Essential HypertensionDie AdrenalektomieCONN'S SYNDROME WITH SEVERE HYPERTENSIONTHE RÔLE OF ACTH, CORTISONE AND HYDROCORTISONE IN SURGERY*†WILLIAM E. ABBOTT, M.D., HARVEY KRIEGER, M.D., STANLEY LEVEY, Ph.D.Surgery of the adrenalsHypertonieManagement of Adrenocortical InsufficiencyAdrenalectomy for HypertensionFURTHER OBSERVATIONS ON PATIENTS WITH SEVERE HYPERTENSION SUBJECTED TO ADRENAL RESECTION AND SYMPATHECTOMY*WILLIAM A. JEFFERS, F.A.C.P., HAROLD A. ZINTEL, F.A.C.S., A. GORMAN HILLS, JOSEPH H. HAFKENSCHIEL, STEPHEN B. LANGFELD, ALFRED M. SELLERS, CHARLES C. WOLFERTH, F.A.C.P.SYMPATHO-ADRENAL SURGERY IN THE MALIGNANT PHASE OF ESSENTIAL HYPERTENSION*SAMUEL T. R. REVELL JR., M.D., F.A.C.P., FRANCIS J. BORGES, M.D., GEORGE H. YEAGER, M.D., F.A.C.S., JAMES G. ARNOLD JR., M.D., RICHARD I. AHLQUIST JR., M.D.Surgical Treatment of HypertensionConstitutional disorders of homeostasis. The genetic aspect of diabetes mellitus, essential hypertension and obesityTHE CLINICAL COURSE, FOLLOWING ADRENAL RESECTION AND SYMPATHECTOMY, OF 82 PATIENTS WITH SEVERE HYPERTENSION*WILLIAM A. JEFFERS, F.A.C.P., HAROLD A. ZINTEL, JOSEPH H. HAFKENSCHIEL, A. GORMAN HILLS, ALFRED M. SELLERS, CHARLES C. WOLFERTH, F.A.C.P.ASSESSMENT OF ADRENOCORTICAL ACTIVITY BY ASSAY OF 17-KETOGENIC STEROIDS IN URINEPharmacologic Aspects of Adrenocortical Steroids and ACTH in ManTHE RÔLE OF THE ADRENAL IN HYPERTENSION*JOHN P. MERRILL, M.D. 1 November 1952Volume 37, Issue 5Page: 972-1005KeywordsCardiovascular diseasesHeartHormonesHospital medicineHypertensionLongitudinal studiesMedical servicesPatientsSurgeryVascular diseases ePublished: 1 December 2008 Issue Published: 1 November 1952 PDF downloadLoading ...