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THE HEREDITY OF GOUT AND ITS RELATIONSHIP TO FAMILIAL HYPERURICEMIA

1949; American College of Physicians; Volume: 31; Issue: 4 Linguagem: Inglês

10.7326/0003-4819-31-4-595

1539-3704

Robert M. Stecher, A. H. Hersh, W.M. Solomon,

Metabolism and Genetic Disorders

Article1 October 1949THE HEREDITY OF GOUT AND ITS RELATIONSHIP TO FAMILIAL HYPERURICEMIAROBERT M. STECHER, M.D., F.A.C.P., A. H. HERSH, Ph.D., WALTER M. SOLOMON, M.D., F.A.C.P.ROBERT M. STECHER, M.D., F.A.C.P.Search for more papers by this author, A. H. HERSH, Ph.D.Search for more papers by this author, WALTER M. SOLOMON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-31-4-595 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite the fact that gout has long been recognized as a hereditary disease and that much study has been devoted to this phase of the problem, the exact pattern of inheritance has not been clearly identified. It seemed likely that a broader concept of the disease and the application of modern methods of genetic investigation to readily available data might add much to our understanding of the disease. The present study was undertaken in the hope that these potentialities might be realized.The most striking features of gout have always been associated with the joint phenomena. Characteristically these consist of...Bibliography1. MCCRACKENOWENPRATT JPPSJH: Gout: still a forgotten disease, Jr. Am. Med. Assoc., 1946, cxxxi, 367-372. CrossrefGoogle Scholar2. BROCHNER-MORTENSEN K: One hundred gouty patients, Acta med. Scandinav., 1941, cvi, 81-107. Google Scholar3. FOLINDAVIS OW: The diagnostic value of uric acid determinations in blood, Arch. Int. Med., 1915, xvi, 33-37. CrossrefGoogle Scholar4. JACOBSON DM: Uric acid in serum of gouty and non-gouty individuals; its determination by Folin's recent method and its significance in the diagnosis of gout, Ann. Int. Med., 1938, xi, 1277-1295. LinkGoogle Scholar5. TALBOTT JH: Serum urate in relatives of gouty patients, Jr. Clin. Invest., 1940, xix, 645-648. CrossrefGoogle Scholar6. SMYTHFREYBERG CJRH: A study of the hereditary nature of gout: a report of two families, Ann. Int. Med., 1942, xvi, 46-56. Google Scholar7. GARROD AB: Observations on certain pathological conditions of the blood and urine in gout rheumatism and Bright's disease, Med.-chir. Trans., London, 1848, xxxi, 83-97. CrossrefGoogle Scholar8. HOGBEN L: Nature and nurture, 1939, W. W. Norton Co., N. Y., p. 76. Google Scholar9. WILLIAMSON CS: Gout, Jr. Am. Med Assoc., 1920, lxxiv, 1625-1629. Google Scholar10. VORHAUSKRAMER MGML: Studies on thiamin chloride in gout, Trans. Am. Therap. Soc., 1938, xxxviii, 109-115. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio*Received for publication April 21, 1947.From the Department of Medicine, School of Medicine at City Hospital and the Department of Biology, Western Reserve University. 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Filipino hyperuricemia in a controlled environmentPopulation Studies of Serum Uric AcidHyperuricemiaThe distribution of serum uric acid values in a population unselected as to gout or hyperuricemiaMalignant Gout with Tophaceous Small Intestine and Megaloblastic AnaemiaGoutObservations on the natural history of hyperuricemia and goutHeberden Oration, 1963 : The Epidemiology of Rheumatic DiseasesAnkylosing Spondylitis, Hyperuricemia, and Anomalies of the Lumbosacral Junction A Family StudyGEORGE R. THOMPSON, M.D., WILLIAM MARTEL, M.D., MILOVAN T. RAKIC, M.D., JOHN T. HAYES, M.D.THE NORMAL RANGE OF PLASMA URATE LEVELSAblagerungskrankheiten körpereigener StoffwechselprodukteHyperuricemia induced by the administration of chlorthalidone and other sulfonamide diureticsReiter's Syndrome in Father and SonHyperuricemia in a male Filipino populationThe Pathogenesis of GoutA Comparative Study of Uric Acid Values of Whole Blood in Patients with Psoriasis and Other Dermatoses11From the Department of Dermatology and Syphilology and The Institute of Industrial Health, University of Michigan Medical School, Ann Arbor, Michigan.Hyperuricemia and Psoriasis**From the Depts. of Dermatology, Dartmouth Medical School and Hitchcock Clinic, Hanover, New Hampshire.Supported in part by grant 89 of the Hitchcock Foundation, Hanover, New Hampshire.Presented at the Twenty-first Annual Meeting of The Society for Investigative Dermatology, Inc., Miami Beach, Florida, June 13, 1960.PhänogenetikOn the dual etiology of hyperuricemia in primary goutINJURY AND ABSENTEEISM IN SMOKERSHYPERURICÆMIC KIDNEY DISEASEHEREDITY IN PRIMARY GOUTHeritable Disorders of Connective TissueSERUM CHOLESTEROL, URIC ACID AND PROTEINS IN PSORIASIS.Moderne Gichtprobleme Ätiologie, Pathogenese, KlinikTHE BIOLOGICAL SIGNIFICANCE OF URIC ACID AND GUANINE EXCRETIONGenetic factors in diseases of connective tissueHereditary Hypergammaglobulinaemia and Systemic Lupus ErythematosusStörungen des PurinstoffwechselsThe Diagnosis of GoutSerum Uric Acid Levels in Psoriasis11From the Department of Dermatology and Syphilology, University of Michigan Medical School, Ann Arbor, Michigan.The role of the kidney in the pathogenesis and treatment of goutEpidermal Separation with Purified Trypsin11From the Detroit Institute of Cancer Research and Department of Dermatology, Wayne State University College of Medicine, Detroit, Michigan.Indian summer, the autumn crocus, and colchicineReiter's Syndrome in First CousinsManagement of GoutGenetic factors in the diseases of later lifeHereditary Factors in ArthritisGouty Arthritis—Diagnosis and TreatmentHeredity in Gout and HyperuricemiaDie GichtPRIMARY AND SECONDARY GOUT*ALEXANDER B. GUTMAN, M.D., F.A.C.P.RHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., EDWARD W. BOLAND, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., WALLACE GRAHAM, M.D., F.R.C.P. (C), L. MAXWELL LOCKIE, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D.Current principles of management in goutNote on the Genetics of Hypercholesterolemia 1 October 1949Volume 31, Issue 4Page: 595-614KeywordsAdrenocorticotropic hormoneArthritisBlood plasmaGenetic determinismGenetic diseasesGeneticsGoutHeredityHospital medicineUric acid Issue Published: 1 October 1949 PDF downloadLoading ...