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ASEPTIC MENINGITIS, A DISEASE OF DIVERSE ETIOLOGY: CLINICAL AND ETIOLOGIC STUDIES ON 854 CASES

1953; American College of Physicians; Volume: 39; Issue: 4 Linguagem: Inglês

10.7326/0003-4819-39-4-675

1539-3704

Charles V. Adair, Ross L. Gauld, Joseph E. Smadel,

Respiratory viral infections research

Article1 October 1953ASEPTIC MENINGITIS, A DISEASE OF DIVERSE ETIOLOGY: CLINICAL AND ETIOLOGIC STUDIES ON 854 CASESCHARLES V. ADAIR, ROSS L. GAULD, M.D., JOSEPH E. SMADEL, M.D.CHARLES V. ADAIR, ROSS L. GAULD, M.D., JOSEPH E. SMADEL, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-4-675 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSporadic cases of infection of the central nervous system, presumably of viral origin, contribute much of the material received by a virus diagnostic laboratory. The present report is concerned with an analysis of material of this type submitted over a period of 11 years from military personnel, veterans and their dependents in the United States. Almost all of the 854 patients who provide the basis of this study presented clinical findings resembling the syndrome designated by Wallgren as acute aseptic meningitis.1In only a few of the patients was the clinical picture indicative of deep-seated neurologic involvement compatible with the...Bibliography1. Wallgren A: Une nouvelle maladie infectieuse due système nerveux central? Acta pædiat. 4: 158, 1925. CrossrefGoogle Scholar2. SmadelAdair JECV: Laboratory aspects of the differential diagnosis in acute poliomyelitis. Poliomyelitis: papers and discussions presented at the Second International Poliomyelitis Conference, 1952, J. B. Lippincott, Philadelphia, p. 164. Google Scholar3. SmadelBairdWall JERDMJ: A soluble antigen of lymphocytic choriomeningitis. I. Separation of soluble antigen from virus, J. Exper. Med. 70: 53, 1939. CrossrefMedlineGoogle Scholar4. Hammon WM: Encephalitis (arthropod-borne virus encephalitides and lymphocytic choriomeningitis): chapter in Diagnostic procedures for virus and rickettsial diseases, 1948, American Public Health Association, New York, p. 187. Google Scholar5. Rogers NG: The effect of Merthiolate on the infectivity of certain viruses, J. Lab. and Clin. Med. 38: 483, 1951. MedlineGoogle Scholar6. SmadelWall JEMJ: Identification of the virus of lymphocytic choriomeningitis, J. Bact. 41: 421, 1941. CrossrefMedlineGoogle Scholar7. EndersCohen JFS: Detection of antibody by complement-fixation in sera of man and monkey convalescent from mumps, Proc. Soc. Exper. Biol. and Med. 50: 180, 1942. CrossrefGoogle Scholar8. Habel K: Cultivation of mumps virus in the developing chick embryo and its application to studies of immunity to mumps in man, Pub. Health Rep. 60: 201, 1945. CrossrefMedlineGoogle Scholar9. LevensEnders JHJF: The hemoagglutinative properties of amniotic fluid from embryonated eggs infected with mumps virus, Science 102: 117, 1945. CrossrefMedlineGoogle Scholar10. BurnetLush FMD: The inactivation of herpes virus by immune sera: experiments using the chorio-allantoic membrane technique, J. Path. and Bact. 48: 275, 1939. CrossrefGoogle Scholar11. BurnetWilliams FMSW: Herpes simplex: a new point of view, M. J. Australia 1: 637, 1939. CrossrefGoogle Scholar12. SchüffnerMochtar WA: Versuche zur Aufteilung von Leptospirenstämmen, mit einleitenden Bemerkungen über den Verlauf von Agglutination und Lysis, Zentralbl. f. Bakt. 101: 405, 1927. Google Scholar13. GochenourYagerWetmoreHightower WSRHPWJA: Laboratory diagnosis of leptospirosis, Am. J. Pub. Health 43: 405-410, 1953. CrossrefGoogle Scholar14. Rasmussen AF: The laboratory diagnosis of lymphocytic choriomeningitis and mumps, Rocky Mountain Conference on Infantile Paralysis, 1946, University of Colorado School of Medicine and Hospitals, Denver, p. 45. Google Scholar15. Havens WP: Lymphocytic choriomeningitis—report of a case occurring in a granary harboring infected mice, J. A. M. A. 137: 857, 1948. CrossrefMedlineGoogle Scholar16. LépineMollaretKreis PPG: Réceptivité de l'homme au virus murin de la chorioméningite lymphocytaire. Reproduction expérimentale de la meningite lymphocytaire bénigne, Compt. rend. Acad. d. sc. 204: 1846, 1937. Google Scholar17. SmadelWall JEMJ: A soluble antigen of lymphocytic choriomeningitis. III. Independence of anti-soluble substance antibodies and neutralizing antibodies, and the rôle of soluble antigen and inactive virus in immunity to infection, J. Exper. Med. 72: 389, 1940. CrossrefMedlineGoogle Scholar18. BangBang HOJ: Involvement of central nervous system in mumps, Acta med. Scandinav. 113: 487, 1943. CrossrefGoogle Scholar19. Silver H: Meningitis in mumps, Acta med. Scandinav. 88: 355, 1936. Google Scholar20. LevisonThordarson HO: Mumps meningitis and meningo-encephalitis, Acta med. Scandinav. 112: 314, 1942. CrossrefGoogle Scholar21. Steinberg CL: Mumps meningo-encephalitis, U. S. Nav. M. Bull. 42: 567, 1944. Google Scholar22. FoxGrotts MJBF: Central nervous system involvement in parotitis, J. Pediat. 35: 561, 1949. CrossrefMedlineGoogle Scholar23. EndersCohenKane JFSLW: Immunity in mumps. II. The development of complement-fixing antibody and dermal hypersensitivity in human beings following mumps, J. Exper. Med. 81: 119, 1945. CrossrefMedlineGoogle Scholar24. Afzelius-Alm L: Aseptic encephalomeningitides in Gothenburg 1932-1950, Acta med. Scandinav. Suppl. 263: 1951. MedlineGoogle Scholar25. JanbonChaptalLabraque-Bordenave MJM: Le problème de la méningite herpétique. Contribution a son étude clinique et expérimentale, Presse méd. 50: 145, 1942. Google Scholar26. GajdusekRobbinsRobbins DCMLFC: Diagnosis of herpes simplex infections by the complement-fixation test, J. A. M. A. 149: 235, 1952. CrossrefMedlineGoogle Scholar27. CoffeyDravinDine JHIWC: Swineherd's disease (aseptic meningitis) d ue to Leptospira pomona , J. A. M. A. 147: 949, 1951. CrossrefMedlineGoogle Scholar28. BeesonHankey PBDD: Leptospiral meningitis, Arch. Int. Med. 89: 575, 1952. CrossrefGoogle Scholar29. CasalsOlitskyAnslow JPKRO: A specific complement-fixation test for infection with poliomyelitis virus, J. Exper. Med. 94: 123, 1951. CrossrefMedlineGoogle Scholar30. RobbinsEndersWellerFlorentino FCJFTHGL: Studies on the cultivation of poliomyelitis viruses in tissue culture. V. The direct isolation and serologic identification of virus strains in tissue culture from patients with non-paralytic and paralytic poliomyelitis, Am. J. Hyg. 54: 286, 1951. MedlineGoogle Scholar31. SabinAring ABCD: Meningo-encephalitis in man caused by the virus of lymphogranuloma venereum, J. A. M. A. 120: 1376, 1942. CrossrefGoogle Scholar32. BernsteinWolff TCHG: Involvement of the nervous system in infectious mononucleosis, Ann. Int. Med. 33: 1120, 1950. LinkGoogle Scholar33. BeloffGang JSKM: Acute poliomyelitis and acute infectious lymphocytosis. Their apparent simultaneous occurrence in a summer camp, J. Pediat. 26: 586, 1945. CrossrefGoogle Scholar34. ShawMelnickCurnen EWJLEC: Infection of laboratory workers with Coxsackie viruses, Ann. Int. Med. 33: 32, 1950. LinkGoogle Scholar35. SmadelWarren JEJ: The virus of encephalomyocarditis and its apparent causation of disease in man, J. Clin. Investigation 26: 1197, 1947. MedlineGoogle Scholar36. DickBestHaddowSmithburn GWAMAJKC: Mengo encephalomyelitis. A hitherto unknown virus affecting man, Lancet 2: 286, 1948. CrossrefMedlineGoogle Scholar37. WarrenSmadelRuss JJESB: The family relationship of encephalomyocarditis, Columbia-SK, MM, and Mengo encephalomyelitis viruses, J. Immunol. 62: 387, 1949. MedlineGoogle Scholar38. Smithburn KC: Studies on certain viruses isolated in the tropics of Africa and South America. Immunological reactions as determined by cross-neutralization tests, J. Immunol. 68: 441, 1952. MedlineGoogle Scholar39. HammonReeves WMWC: California encephalitis virus. A newly described agent, California Med. 77: 303, 1952. MedlineGoogle Scholar40. Verlindevan der WerffBriët JDJW: An encephalitis epidemic caused by the virus of lymphocytic choriomeningitis, Ant. v. Leeuwenhoek 14: 33, 1948. CrossrefMedlineGoogle Scholar41. AdamsKubik RDCS: The morbid anatomy of the demyelinative diseases, Am. J. Med. 12: 510, 1952. CrossrefMedlineGoogle Scholar42. Mollaret P: La méningite endothélioleukocytaire multirécurrente bénigne. Syndrome nouveau ou maladie nouvelle. Documents humoreaux et microbiologiques, Ann. Inst. Pasteur 154: 1, 1945. Google Scholar43. Nordwall G: Über fälle zellulärer, aseptischer Meningitis, Acta psychiat. et neurol. 9: 285, 1934. CrossrefGoogle Scholar44. SabinEichenwaldFeldmanJacobs ABHHAL: Present status of clinical manifestations of toxoplasmosis in man, J. A. M. A. 150: 1063, 1952. CrossrefMedlineGoogle Scholar45. MosbergArnold WHJG: Torulosis of the central nervous system: review of the literature and report of five cases, Ann. Int. Med. 32: 1153, 1950. LinkGoogle Scholar46. MerrittMoore HHM: Acute syphilitic meningitis, Medicine 14: 119, 1935. CrossrefGoogle Scholar47. FarmerJaneway TWCA: Infections with the virus of lymphocytic choriomeningitis, Medicine 21: 1, 1942. CrossrefGoogle Scholar48. DuncanThomasTobin PRAEJO: Lymphocytic choriomeningitis, review of 10 cases, Lancet 1: 956, 1951. CrossrefMedlineGoogle Scholar49. KolmerFreeseMatsunamiMeine JAAETBM: Studies of the cerebrospinal fluid in acute anterior poliomyelitis, Am. J. M. Sc. 154: 720, 1917. CrossrefGoogle Scholar50. MerrittFremont-Smith HHF: The cerebrospinal fluid, 1937, W. B. Saunders Company, Philadelphia, p. 94. Google Scholar51. LillieArmstrong RDC: Pathologic reaction to the virus of lymphocytic choriomeningitis in guinea pigs, Pub. Health Rep. 59: 1391, 1944. CrossrefMedlineGoogle Scholar52. ArmstrongWooleyOnstott CJGRH: Distribution of lymphocytic choriomeningitis virus in the organs of experimentally inoculated monkeys, Pub. Health Rep. 51: 298, 1936. CrossrefGoogle Scholar53. ScottRivers TFTM: Meningitis in man caused by a filterable virus. I. Two cases and the method of obtaining a virus from their spinal fluids, J. Exper. Med. 63: 397, 1936. CrossrefMedlineGoogle Scholar54. SmadelGreenPaultaufGonzales JERHRMTA: Lymphocytic choriomeningitis: two human fatalities following an unusual febrile illness, Proc. Soc. Exper. Biol and Med. 49: 683, 1942. CrossrefGoogle Scholar55. FindlayAlcockStern GMNSRO: The virus aetiology of one form of lymphocytic meningitis, Lancet 1: 650, 1936. CrossrefGoogle Scholar56. MacCallumFindlay FOGM: Lymphocytic choriomeningitis. Isolation of the virus from the nasopharynx, Lancet 1: 1370, 1939. CrossrefGoogle Scholar57. BarkerFord LFFR: Chronic arachnoiditis obliterating the spinal subarachnoid space, J. A. M. A. 109: 785, 1937. CrossrefGoogle Scholar58. MachellaWeinbergerLippincott TELMSW: Lymphocytic choriomeningitis. Report of a fatal case with autopsy findings, Am. J. M. Sc. 197: 617, 1939. CrossrefGoogle Scholar59. WendkosNoll MHJ: Myocarditis caused by epidemic parotitis, Am. Heart J. 27: 414, 1944. CrossrefGoogle Scholar60. Rosenberg DH: Acute myocarditis in mumps (epidemic parotitis), Arch. Int. Med. 76: 257, 1945. CrossrefGoogle Scholar61. Armstrong C: Some recent research in the field of neurotropic viruses with especial reference to lymphocytic choriomeningitis and herpes simplex, Mil. Surgeon 91: 129, 1942. Google Scholar62. GordonHeeren JERH: The epidemiology of mumps, Am. J. M. Sc. 200: 1940. Google Scholar63. YagerGochenour RHWS: Leptospirosis in North America, Am. J. Trop. Med. and Hyg. 1: 457, 1952. CrossrefMedlineGoogle Scholar64. Smadel JE: Aseptic meningitis of known and unknown etiology, J. Clin. Investigation 21: 646, 1942. Google Scholar65. Sigel MM: From table in Chapter on Viral Encephalitides in Coriell, L. L., Principles of internal medicine, 1950, Blakiston Co., Philadelphia, p. 1065. Google Scholar66. Broom JC: Leptospirosis in England and Wales, Brit. M. J. 2: 689, 1951. CrossrefMedlineGoogle Scholar67. KaneEnders LWJF: Immunity in mumps. III. The complement-fixation test as an aid in the diagnosis of mumps meningo-encephalitis, J. Exper. Med. 81: 137, 1945. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Received for publication April 15, 1953.From the Department of Virus and Rickettsial Diseases, Army Medical Service Graduate School, Walter Reed Army Medical Center, Washington, D. C. 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REAM, M.D., JOHN W. HESSING, M.D.CURRENT TREATMENT OF TUBERCULOUS MENINGITIS: A PRELIMINARY REPORT*EUGENE J. DES AUTELS, M.D., F.A.C.P., KARL H. PFUETZE, M.D.Aseptic meningitisCurrent pediatric referencesCERTIFICATION AND DETENTIONASEPTIC MENINGITIS 1 October 1953Volume 39, Issue 4Page: 675-704KeywordsArmed forcesCentral nervous systemEtiologyGraduate medical educationMedical servicesMeningitisResearch laboratoriesRocky Mountain spotted feverViral diseases ePublished: 1 December 2008 Issue Published: 1 October 1953 Copyright & PermissionsCopyright, 1953, by The American College of PhysiciansPDF downloadLoading ...