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Methylisothiazolinone is categorised as a strong sensitiser in the M urine L ocal L ymph N ode A ssay

2013; Wiley; Volume: 69; Issue: 5 Linguagem: Inglês

10.1111/cod.12167

1600-0536

David W. Roberts,

Allergic Rhinitis and Sensitization

Contact DermatitisVolume 69, Issue 5 p. 261-262 Editorial Methylisothiazolinone is categorised as a strong sensitiser in the Murine Local Lymph Node Assay David W. Roberts, David W. RobertsSearch for more papers by this author David W. Roberts, David W. RobertsSearch for more papers by this author First published: 12 October 2013 https://doi.org/10.1111/cod.12167Citations: 22Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1Lundov M D, Krongaard T, Menné T L, Johansen J D. Methylisothiazolinone contact allergy a review. Br J Dermatol 2011: 165: 1178–1182. 2Geier J, Lessman H, Schnuch A, Uter W. Recent increase in allergic reactions to methylchloroisothiazolinone/methylisothiazolinone: is methylisothiazolinone the culprit? Contact Dermatitis 2012: 67: 334–341. 3Alvarez-Sánchez R, Basketter D, Pease C, Lepoittevin J-P. Studies of chemical selectivity of hapten, reactivity, and skin sensitization. 3. Synthesis and studies on the reactivity toward model nucleophiles of the 13C-labeled skin sensitisers, 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI). Chem Res Toxicol 2003: 16: 627–636. 4Aptula A O, Roberts D W, Cronin M T D. From experiment to theory: molecular orbital parameters to interpret the skin sensitization potential of 5-chloro-2-methylisothiazol-3-one and 2-methylisothiazol-3-one. Chem Res Toxicol 2005: 18: 324–329. 5Natsch A, Haupt T, Laue H. Relating skin sensitizing potency to chemical reactivity: reactive Michael acceptors inhibit NF-κB signaling and are less sensitizing than S(N)Ar- and S(N)2- reactive chemicals. Chem Res Toxicol 2011: 24: 2018–2027. 6Roberts D W, Patlewicz G, Kern P S et al. Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization. Chem Res Toxicol 2007: 20: 1019–1030. 7Gerberick G F, Ryan C A, Kern P S et al. Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods. Dermatitis 2005: 16: 157–202. 8Basketter D A, Gilmoour N J, Wright Z et al. Biocides: characterization of the allergenic hazard of methylisothiazolinone. Cutan Ocul Toxicol 2003: 22: 187–199. 9Estrada E, Patlewicz G, Chamberlain M et al. Computer-aided knowledge generation for understanding skin sensitization mechanisms: the TOPS-MODE approach. Chem Res Toxicol 2003: 16: 1226–1235. Citing Literature Volume69, Issue5November 2013Pages 261-262 ReferencesRelatedInformation