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Fingernails and Toenails as Biomarkers of Subchronic Exposure to Fluoride from Dentifrice in 2- to 3-Year-Old Children

2004; Karger Publishers; Volume: 38; Issue: 2 Linguagem: Inglês

10.1159/000075934

1421-976X

Maria Heloísa Corrêa Rodrigues, José Roberto de Magalhães Bastos, Marília Afonso Rabelo Buzalaf,

Bone and Dental Protein Studies

This work evaluated the use of fingernails and toenails as biomarkers of subchronic exposure to fluoride (F) from fluoride dentifrice (FD) in 2- to 3-year-old children. Ten 2- to 3-year-old children used a placebo dentifrice (without F) for 28 days, FD (1,570 ppm F as monofluorophosphate) for the following 28 days, and then placebo dentifrice for an additional 28 days, then returned to their usual dentifrices. Fingernails and toenails were clipped every 2 weeks, during the experimental period and for an additional 22 weeks. Nail F was analyzed by electrode following hexamethyldisiloxane-facilitated diffusion. There were no significant differences between fingernail and toenail F concentrations. Mean peak F concentrations occurred 16 weeks after starting the use of FD. Results suggest that fingernails and toenails may be suitable biomarkers of subchronic exposure to F from FD in small children.