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The role of the exocrine pancreas in the stimulation of insulin secretion by intestinal hormones

1971; Springer Science+Business Media; Volume: 7; Issue: 2 Linguagem: Inglês

10.1007/bf00443883

1432-0428

R. Goberna, R. Fußgänger, S. Raptis, M. Telib, E. F. Pfeiffer,

Diabetes and associated disorders

A comparison was made of the effects of the intestinal hormones secretin and pancreozymin on insulin secretion in non-diabetic rats with experimentically induced exocrine pancreatic insufficiency and in control animals. The rats with exocrine pancreatic insufficiency exhibited normal disappearence of glucose and secretion of insulin. In rats with exocrine pancreatic insufficiency secretin did not lead to any increase in insulin secretion in contrast to its effect in the controls. In rats with exocrine pancreatic insufficiency pancreozymin evoked secretion of insulin to the same extent as in the normal animals. — From these results it is inferred that the effect of secretion upon the β-cells of the rat is dependent upon the presence of intact exocrine pancreatic tissue. However, pancreozymin and glucose exert their effects upon the β-cells directly without the involvement of the exocrine portion of the pancreas. All of these findings made under conditions in vivo are in perfect accord with studies made on isolated islets of rats subjected to the same stimuli in the preparation in vitro.