THE METABOLISM OF GLUTARIC ACID-1,5-C14
1952; Elsevier BV; Volume: 199; Issue: 1 Linguagem: Inglês
10.1016/s0021-9258(18)44826-0
ISSN1083-351X
AutoresMorton Rothstein, Leon L. Miller,
Tópico(s)Analytical Chemistry and Chromatography
ResumoThis paper establishes the fact that t.he normal and phlorhizinized rat can rapidly metabolize large amounts of glutaric acid.Experimental evidence is presented, indicating the possible routes by which glutaric acid-1, 5-Cl4 is converted to radioactive carbon dioxide, glucose-3 ,4-C14, acetoacetic acid-l-C14, and a radioactive 2-carbon fragment.Glutaric acid has been fed to humans and does not appear in the urine in significant amounts, and, unlike longer chain dicarboxylic acids, appears to be largely utilized (1).In addition, it has been suggested as a product of lysine breakdown in guinea pig liver homogenates (2).Beyond this, little appears to be known about glutarate metabolism.EXPERIMENTAL Preparation of Glutaric Acid-l ,5-C14-This acid was prepared by hydrochloric acid hydrolysis of glutaronitrile-1 , 5-C14.The latter compound was isolated as a by-product of the synthesis of r-chlorobutyronitrile used in the preparation of e-C14-DL-lySine (3).
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