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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Amoxicillin/clavulanic acid‐warfarin drug interaction: a randomized controlled trial

2010; Wiley; Volume: 71; Issue: 2 Linguagem: Inglês

10.1111/j.1365-2125.2010.03824.x

ISSN

1365-2125

Autores

Qian Zhang, Guy G. Simoneau, Céline Verstuyft, Ludovic Drouet, Claire Bal dit Sollier, Jean‐Claude Alvarez, N. Rizzo, Jean‐François Bergmann, Laurent Becquemont, Stéphane Mouly,

Tópico(s)

Pharmacological Effects of Natural Compounds

Resumo

To investigate whether an interaction exists between amoxicillin/clavulanic acid (amoxiclav) and warfarin in patients treated with stable oral anticoagulant therapy.In a double-blind, cross-over, placebo-controlled study, 12 patients on stable warfarin therapy, received a 7 day amoxiclav regimen or placebo.The mean maximum increase in INR observed was 0.22 ± 0.3 with amoxiclav vs. 0.24 ± 0.6 with placebo (P=0.94). The day 7-day 1 factor II, R(-) and S(-) warfarin plasma concentrations were similar during the amoxiclav and placebo study periods (P=0.81, P=0.45, P=0.75, respectively).Amoxiclav did not modify anticoagulation in patients treated with stable warfarin therapy and without infection.

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