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Chorionic Villus Sampling Prior to Pregnancy Termination, a Tool for Forensic Paternity Testing

1999; Wiley; Volume: 44; Issue: 5 Linguagem: Inglês

10.1520/jfs12044j

1556-4029

Ayeleth Reshef, P Brauner, Moshe Shpitzen, N. Gallili, A. Herbert Marbach, Uzi Motro, E. Shmueli, Vardiella Meiner,

Fetal and Pediatric Neurological Disorders

Chorionic villus sampling (CVS), prior to pregnancy termination (pre-termination CVS), is suggested as a tool for forensic paternity testing. Unlike the abortion material, which consists of ruptured tissues of fetal and maternal origin, extra-embryonic membranes obtained through CVS can provide an uncontaminated source of fetal tissue for genotyping. We discuss the possibility of confined placental mosaicism (CPM) and its implications on the polymerase chain reaction (PCR) based analyses of short tandem repeats (STRs) and the D1S80 loci.