Pain and Nociception
1984; Wiley; Linguagem: Inglês
10.1002/cphy.cp010320
ISSN2040-4603
Autores Tópico(s)Neurotransmitter Receptor Influence on Behavior
ResumoThe sections in this article are: 1 Concepts and Theories 2 Pain as A Physiological Reaction 3 Aberrant Pain 3.1 Inflammation and Hyperalgesia 3.2 Referred Pain 3.3 Pain Associated With Pathology of Nervous System 4 Primary Afferent Neurons 4.1 Afferent Fiber Size and Quality of Pain 4.2 Identity of Receptive Units 4.2.1 Mechanical Nociceptors of Skin 4.2.2 Polymodal Nociceptors of Skin 4.2.3 Other Cutaneous Nociceptors 4.2.4 Nociceptors in Muscle 4.2.5 Nociceptors in Other Subcutaneous Tissues 4.3 Noxious Stimulation of Low-Threshold Sense Organs 4.4 Relationship of Nociceptor Activity to Pain 4.5 Chemical Mediators 4.6 Central Terminations of Primary Afferent Fibers 4.6.1 Morphological Considerations 4.6.2 Synaptic Transmission 5 Ascending Sensory Pathways 5.1 Defining Pathways for Pain Sensation 5.2 Selectively Nociceptive Neurons of Spinal Cord and Trigeminal Nuclei 5.3 Nonselectively Nociceptive Excitation 5.4 Origins of Spinothalamic and Related Systems 5.5 Functional Attributes of Neurons Projecting Over Ventral Quadrant Tracts 5.6 Projection Pathways for the Face 5.7 Other Ascending Pathways 5.8 Brain Stem, Hypothalamic, and Thalamic Components 5.8.1 Medulla and Mesencephalon 5.8.2 Hypothalamus 5.8.3 Thalamus 5.8.4 Intralaminar and Other Medial Nuclei 5.9 Cerebral Cortex 6 Modulation of Nociceptive Neurons 6.1 Afferent Modulation 6.2 Descending Effects 6.3 Opiate Receptors, Opioids, and Endorphins 6.3.1 Opiate Receptors and Endogenous Ligands 6.3.2 Descending Opiate-Initiated Mechanisms 6.4 Cellular Mechanisms of Modulation 6.4.1 Signs of Presynaptic Action 6.4.2 Primary Afferent Hyperpolarization 6.4.3 Enkephalin Action 6.4.4 Locus of Inhibition 6.5 Higher Level Interactions 6.6 Functional Significance of Modulatory Mechanisms 7 Recapitulation
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