High relapse rate after discontinuation of adjunctive medication for elderly patients with recurrent major depression
1996; American Psychiatric Association; Volume: 153; Issue: 11 Linguagem: Inglês
10.1176/ajp.153.11.1418
ISSN1535-7228
AutoresCharles F. Reynolds, Ellen Frank, J M Perel, Sati Mazumdar, Mary Amanda Dew, Amy Begley, Patricia R. Houck, Martica H. Hall, Benoit H. Mulsant, M. Katherine Shear, Mark D. Miller, Cleon Cornes, David J. Kupfer,
Tópico(s)Bipolar Disorder and Treatment
ResumoBack to table of contents Previous article Next article No AccessHigh relapse rate after discontinuation of adjunctive medication for elderly patients with recurrent major depressionPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.153.11.1418AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: The authors documented outcomes of elderly depressed patients requiring adjunctive medication during acute-phase pharmacotherapy because of slow or partial response to nortriptyline. Twenty-eight patients (17.7%) received inpatient care at some point during acute-phase treatment. METHOD: Rates of response, relapse, and sustained remission were examined in 158 elderly patients with recurrent major depression, grouped by whether they received brief treatment with adjunctive medication (lithium, perphenazine, or paroxetine) (N = 39) or did not (N = 119). RESULTS: The group receiving adjunctive medication had a lower rate of response to acute therapy (64.1% versus 83.2%), a higher relapse rate during continuation therapy (52.0% versus 6.1%), and a lower rate of sustained remission (recovery) (48.7% versus 76.5%) than did the group without augmentation. CONCLUSIONS: Elderly depressed patients requiring augmented pharmacotherapy to achieve remission may need continuation of adjunctive medication to remain well and to avoid early relapse. Alternatively, factors that lead to augmentation in the first place (e.g., heightened anxiety) may also increase the risk of relapse. Access content To read the fulltext, please use one of the options below to sign in or purchase access. 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Smith, Ph.D., Charles F. ReynoldsIII, M.D., Bruce Pollock, M.D., Ph.D., Stuart Derbyshire, Ph.D., Eric Nofzinger, Ph.D., Mary Amanda Dew, Ph.D., Patricia R. Houck, M.S.H., Donna Milko, B.S., C.N.M.T., R.T.(N.), Carolyn Cidis Meltzer, M.D., and David J. Kupfer, M.D.1 May 1999 | American Journal of Psychiatry, Vol. 156, No. 5The American Journal of Geriatric Psychiatry, Vol. 7, No. 1Treatment-Resistant Depression in Late Life1 December 1998 | Journal of Geriatric Psychiatry and Neurology, Vol. 11, No. 4Management of Anxiety in Late Life1 December 1998 | Journal of Geriatric Psychiatry and Neurology, Vol. 11, No. 4How Common Is Resistance to Treatment in Recurrent, Nonpsychotic Geriatric Depression?John T. Little, M.D., Charles F. ReynoldsIII, M.D., Mary Amanda Dew, Ph.D., Ellen Frank, Ph.D., Amy E. Begley, M.A., Mark D. Miller, M.D., Cleon Cornes, M.D., Sati Mazumdar, Ph.D., James M. Perel, Ph.D., and David J. Kupfer, M.D.1 August 1998 | American Journal of Psychiatry, Vol. 155, No. 8International Journal of Geriatric Psychiatry, Vol. 13, No. 3Current Opinion in Psychiatry, Vol. 11, No. 4 Volume 153Issue 11 November 1996Pages 1418-1422 Metrics PDF download History Published online 1 April 2006 Published in print 1 November 1996
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