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The Relationship of Herpesvirus to Carcinoma of the Prostate

1981; Lippincott Williams & Wilkins; Volume: 125; Issue: 3 Linguagem: Inglês

10.1016/s0022-5347(17)55039-9

1527-3792

Larry Baker, Winston K. Mebust, Tom D. Y. Chin, A. L. Chapman, Daniel R. Hinthorn, Daniel Towle,

Cytomegalovirus and herpesvirus research

No AccessJournal of Urology1 Mar 1981The Relationship of Herpesvirus to Carcinoma of the Prostate Larry H. Baker, Winston K. Mebust, Tom D.Y. Chin, A.L. Chapman, Daniel Hinthorn, and Daniel Towle Larry H. BakerLarry H. Baker , Winston K. MebustWinston K. Mebust , Tom D.Y. ChinTom D.Y. Chin , A.L. ChapmanA.L. Chapman , Daniel HinthornDaniel Hinthorn , and Daniel TowleDaniel Towle View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)55039-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail A laboratory based epidemiologic study was done to determine the possible relationship of herpesvirus type 2 to carcinoma of the prostate. A total of 305 patients (224 with benign prostatic hypertrophy and 81 with prostatic carcinoma) who underwent transurethral resection of the prostate was studied. Viral cultures were obtained from urethral swabs and urine preoperatively. Prostatic tissue removed at operation was grown as tissue explants, using a monolayer cell culture technique, and examined by specific immunofluorescence and electron microscopy for evidence of herpesvirus type 2. The sera of the patients also were tested for specific antibody to herpesvirus type 2 by the indirect hemagglutination inhibition test. Although herpesvirus was not isolated 5 per cent of the patients had evidence of herpesvirus type 2 antigen in prostatic tissues by specific immunofluorescence. Electron microscopy failed to reveal the presence of viral particles. There was an increased prevalence of herpesvirus type 2 antibody in patients with carcinoma of the prostate compared to the controls with benign prostatic hypertrophy (p less than 0.05). Although marital status was similar the patients with prostatic cancer tended to marry at an earlier age, have more children, more sexual partners and more exposure to prostitutes than their counterparts with benign prostatic hypertrophy. The demonstration of specific herpesvirus type 2 antibody in patients with prostatic cancer supports an etiologic role for herpesvirus type 2 but further studies are needed to describe more definitively the relationship since the indexes of sexual activity are remarkably high in both groups. © 1981 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byPLATZ E and De MARZO A (2018) Epidemiology of Inflammation and Prostate CancerJournal of Urology, VOL. 171, NO. 2S, (S36-S40), Online publication date: 1-Feb-2004.Ibrahim G, Gravitt P, Dittrich K, Ibrahim S, Melhus O, Anderson S and Robertson C (2018) Detection of Human Papillomavirus in the Prostate by Polymerase Chain Reaction and in Situ HybridizationJournal of Urology, VOL. 148, NO. 6, (1822-1826), Online publication date: 1-Dec-1992.McNicol P and Dodd J (2018) High Prevalence of Human Papillomavirus in Prostate TissuesJournal of Urology, VOL. 145, NO. 4, (850-853), Online publication date: 1-Apr-1991. Volume 125 Issue 3 March 1981 Page: 370-374 Advertisement Copyright & Permissions© 1981 by The American Urological Association Education and Research, Inc.Metrics Author Information Larry H. Baker More articles by this author Winston K. Mebust More articles by this author Tom D.Y. Chin More articles by this author A.L. Chapman More articles by this author Daniel Hinthorn More articles by this author Daniel Towle More articles by this author Expand All Advertisement PDF downloadLoading ...