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GSK3 and Tau: Two Convergence Points in Alzheimer's Disease

2012; IOS Press; Volume: 33; Issue: s1 Linguagem: Inglês

10.3233/jad-2012-129025

1875-8908

Félix Hernández, José J. Lucas, Jesús Ávila,

Prion Diseases and Protein Misfolding

Glycogen synthase kinase 3 (GSK3) is a ubiquitously expressed serine/threonine kinase that plays a key role in the pathogenesis of Alzheimer's disease (AD). GSK3 phosphorylates tau in most serine and threonine residues hyperphosphorylated in paired h