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Clinicopathological features of small nonfunctioning pancreatic neuroendocrine tumors

2014; Baishideng Publishing Group; Volume: 20; Issue: 47 Linguagem: Inglês

10.3748/wjg.v20.i47.17949

2219-2840

M. Furukori, Koji Imai, Hidenori Karasaki, Kenji Watanabe, Kensuke Oikawa, Naoyuki Miyokawa, Masahiko Taniguchi, Hiroyuki Furukawa,

Neuroblastoma Research and Treatments

AIM:To present our experiences in studying the clinicopathological features of small nonfunctioning pancreatic neuroendocrine tumors (NF-pNETs). METHODS:The subjects included 9 patients with NF-pNETs who underwent pancreatectomy between April 1996 and September 2012.The surgical procedure, histopathological findings, and prognosis were assessed. RESULTS:All tumors were incidentally detected by computed tomography.The median diameter was 10 mm (5-32 mm).One patient was diagnosed with von Hippel-Lindau disease, and the others were sporadic cases.For the histopathological findings, 7 patients were G1; 1 patient was G2; and 1 patient, whose tumor was 22 mm, had neuroendocrine carcinoma (NEC).One patient who had a tumor that was 32 mm had direct invasion to a regional lymph node and 1 patient with NEC, had regional lymph node metastases.Six of the 7 patients with sporadic NF-pNETs, excluding the patient with NEC, had tumors that were smaller than 10 mm.Tumors smaller than 10 mm showed no malignancy and lacked lymph node metastasis.CONCLUSION: Sporadic NF-pNETs smaller than 10 mm tend to have less malignant potential.These findings suggest that lymphadenectomy may be omitted for small NF-pNETs after further investigation.